› 1aft

Solution NMR

SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES

Released:
DOI: 10.2210/pdb1aft/pdb
PDB entry 1aft coloured by chain, ensemble of 26 models, front view.
PDB entry 1aft coloured by chain, ensemble of 26 models, side view.
PDB entry 1aft coloured by chain, ensemble of 26 models, top view.
Source organism: Mus musculus
Primary publication:
NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit.
Fisher A, Laub PB, Cooperman BS
Nat Struct Biol 2 951-5 (1995)
PMID: 7583667

Function and Biology Details

Reaction catalysed: 
2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145686 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonucleoside-diphosphate reductase subunit M2 Chain: A
Molecule details ›
Chain: A
Length: 8 amino acids
Theoretical weight: 854 Da
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P11157 (Residues: 384-390; Coverage: 2%)
Gene name: Rrm2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING IMPLEMENTED WITH RESTRAINED MOLECULAR DYNAMICS
Expression system: Not provided

Quick links

Citations

3 review citations

The structural basis for the allosteric regulation of ribonucleotide reductase.
Ahmad et al. (2013)
2 more