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BioModels is a repository of mathematical models of biological and biomedical systems. It hosts a vast selection of existing literature-based physiologically and pharmaceutically relevant mechanistic models in standard formats. Our mission is to provide the systems modelling community with reproducible, high-quality, freely-accessible models published in the scientific literature. More information about using BioModels such as model submission, update, publication, or reviewers access can be found in the FAQ.

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1,132 classes
1,073 models
1,537 models
833 models
1,132 classes

Model of The Month

May,  2024

Protein synthesis and post-translational modification

Our model prevents the intuitive misinterpretation of proteomics data by enabling the interpretation of these data in a way that is impossible without a model. When a protein exists in multiple proteoforms, such as when measuring unmodified and modified proteoforms of the same protein, the biological interpretation of pSILAC data becomes non-trivial. We demonstrate that for interconvertible proteoforms, metabolic labelling does not provide direct information on differences in protein stability as previously suggested based on intuition alone. Measured clearance profiles rather tie into the relative order of modifications along the lifetime of a protein, with early modification exhibiting faster clearance than later ones.

Model(s) associated with this Model of the Month: BIOMD0000001078.

Last updated by: Eva-Maria Geissen


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How to cite BioModels

Rahuman S Malik-Sheriff, Mihai Glont, Tung V N Nguyen, Krishna Tiwari, Matthew G Roberts, Ashley Xavier, Manh T Vu, Jinghao Men, Matthieu Maire, Sarubini Kananathan, Emma L Fairbanks, Johannes P Meyer, Chinmay Arankalle, Thawfeek M Varusai, Vincent Knight-Schrijver, Lu Li, Corina Dueñas-Roca, Gaurhari Dass, Sarah M Keating, Young M Park, Nicola Buso, Nicolas Rodriguez, Michael Hucka, and Henning Hermjakob
Nucl. Acids Res. 2020
Mihai Glont, Tung V N Nguyen, Martin Graesslin, Robert Hälke, Raza Ali, Jochen Schramm, Sarala M Wimalaratne, Varun B Kothamachu, Nicolas Rodriguez, Maciej J Swat, Jurgen Eils, Roland Eils, Camille Laibe, Rahuman S Malik-Sheriff, Vijayalakshmi Chelliah, Nicolas Le Novère, and Henning Hermjakob
Nucl. Acids Res. 2018
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