- Course overview
- Search within this course
- What is InterPro?
- What is an InterPro entry?
- How to search InterPro?
- Summary
- Quiz
- Exercise: analyse a protein sequence
- Your feedback
- Get help and support on InterPro
- References
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Summary
- InterPro is a resource for classifying proteins into families and predicting domains, repeats and functional sites.
- InterPro integrates protein signatures from 13 member databases that are part of the InterPro consortium: CATH-Gene3D, CDD, HAMAP, PANTHER, Pfam, PIRSF, PRINTS, PROSITE Patterns, PROSITE Profiles, SFLD, SMART, SUPERFAMILY and TIGRFAMs. Protein signatures are predictive models based on similarities among proteins that have the same structure or function.
- You can search InterPro with an amino acid or nucleotide sequence using the website.
- The InterPro website can also be searched with a word or phrase, an entry identifier or short name, UniProtKB accessions and short names, gene, GO terms, PDB, set, proteome or taxonomy identifiers.
- The InterPro website integrates a browse search functionality.
- Batches of sequences can be searched against InterPro by submitting multiple amino acid or nucleotice sequences when using the Search by sequence in the InterPro website, downloading the InterProScan tool, or using the EBI’s web services.
- The InterPro protein view provides a graphical representation of the signatures that match a particular protein, with information about protein family membership, sequence features, structural features, and structural predictions for that protein.
- The InterPro structure view provides a graphical representation of the signatures that match a particular protein structure with a 3D structure viewer, information about the chains secondary structures, InterPro entries and member database signatures membership.