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Want to know how we did it?

When you search InterPro with the FASTA sequence provided, you will get a graphical representation of results, similar to that shown in Figure 25.

Figure 25 InterPro sequence search results overview page.

What information can I extract from the results?

  • The protein is predicted to contain an N-terminal signalling domain, which is part of a wider class of domains that also includes the zinc-binding domains of DD-peptidase.
  • The protein is also predicted to contain a C-terminal Hint domain, which is involved in auto-processing of the protein. The Hint domain itself can be broken down into two smaller subdomains.
  • The protein queried is predicted to be a member of the hedgehog protein family, and therefore involved in a range of biological processes, including development and cell-cell signalling. Where can I find this information? From the GO terms and description from entry IPR001657 (Figure 26).
Figure 26 The InterPro entry page for IPR001657 (Hedgehog protein).