Searching with a protein identifier

By searching for a protein accession on the quick search or by clicking on it in the search result list, you’ll be redirected to the InterPro protein page.

The protein page is similar to the sequence search results page, but it contains extra information, drawn from UniProtKB which is displayed at the top of the page in an additional section (Figure 22). It includes information on the name of the protein in UniProtKB, its accession and short name, the gene encoding it, the species in which it is found and its length in amino acids. If the protein belongs to one of the references proteomes in UniprotKB this information will also be displayed here. The ‘Protein family membership‘ section provides information about the InterPro family entries the protein is found in.

On the top right-hand side of the protein page, the external link section will take you to the UniProtKB and AlphaFold and/or BFVD websites (depending on availability) for this protein or allow you to easily start a search in Foldseek.

Additional information can also be found in the left-hand side menu if available:

• Entries lists all the InterPro entries where the protein is found
• Structures lists any PDB structural information for the protein accession searched
• AlphaFold shows the AlphaFold predicted structure for the protein (these links will only be active where such information is present in UniProtKB)
• BFVD shows the predicted structure for the protein (these links will only be active where such information is present in the BFVD website)
• Sequence gives access to the protein sequence with quick access to InterProScan search tool
• Similar proteins lists all UniProtKB proteins with the same domain architecture

In the protein sequence viewer, member database family, domain, homologous superfamily, site and repeat matches are displayed as in the sequence search results page, but extra information is available:

• Intrinsically disordered regions, signal peptide regions, transmembrane regions, coiled regions, cytoplasmic/non-cytoplasmic domains, CATH-Funfams, spurious proteins, eukaryotic linear motifs and Pfam-N annotations…
• Conserved residues annotations are provided by the CDD, SFLD and PIRSR databases.

For an exhaustive list of the information available in the protein sequence viewer, you can have a look at the InterPro documentation.

InterPro-N matches, distinguished by a leading sparkles icon, are predicted using deep learning. You can change the display mode in the Options menu above the sequence protein viewer. However, please note that InterPro-N predictions are not yet available for protein isoforms.