Sequence search results: family information

Looking at the results overview page, we will examine the family that InterPro predicts the query protein to belong to.

On the results page, the family information is available in the Protein family membership section (Figure 16).

On the results page, place your mouse over the member database family matches (coloured bars) in the sequence viewer (Figure 17):

Mousing over one of the member database family representative, we see the member database it belongs to (PIRSF in this case), the InterPro accession number in which it is integrated into if applicable (IPR017281), the member database entry name (MyD88) and its position on the sequence (amino acid residues 1-293).

Click on the InterPro entry name on the right-hand side of the sequence viewer or on the InterPro accession in the tooltip to visit the entry page for ‘myeloid differentiation primary response protein MyD88’ (Figure 18). This page explains what MyD88 is, what its functions are, and the GO terms that can be applied to members of the family.

On the InterPro entry page, clicking on the items in the left-hand side menu allows to examine the different UniProt proteins that are predicted to belong to the family (Proteins), the species in which they are found (Taxonomy), the reference proteomes in which they are found (Proteomes), their solved protein structures (Structures), their predicted protein structures (AlphaFold) and the pathways the proteins are involved in (Pathways).

Clicking on any of these menu items opens a new tab with the appropriate information and links that allow you to download specific datasets (e.g., all the proteins in a family, or all the protein family members from a particular kingdom, class or species).