Mechanism and Catalytic Site Atlas

Plot Type:	Bar MultiBar Scatter Propensity Heatmap Conservation Heatmap
Data Type:	Residue Count Role Count Conservation by Function Pseudoenzymes Distribution Multi Species Distribution Multi Active Site Conservation Residue Role Conservation Propensity Vs Conservation Catalytic Propensity Residues Vs Roles Residues Vs Target Atoms Residues Vs Target Envs Conservation
Function Location:	Side Chain Post-Translation Modification Main Chain Amine Main Chain Carbonyl Main Chain C-terminus Main Chain N-terminus Main Chain
Function Type:	Interaction Reactant Spectator
Function:	activator alter redox potential attractive charge-charge interaction covalent catalysis covalently attached decrease redox potential electrofuge electron pair acceptor electron pair donor electron pair relay electron pair shuttle electron shuttle electron tunneling medium electrophile electrostatic destabiliser electrostatic interaction electrostatic stabiliser enhance reactivity ground state destabiliser hydride acceptor hydride donor hydride relay hydride shuttle hydrogen bond acceptor hydrogen bond donor hydrogen radical acceptor hydrogen radical donor hydrogen radical relay hydrogen radical shuttle hydrophobic interaction increase acidity increase basicity increase electrophilicity increase nucleophilicity increase redox potential leaving group (radical) metal ligand modifies pKa nucleofuge nucleophile pi-pi interaction polar interaction polar/non-polar interaction promote heterolysis promote homolysis proton acceptor proton donor proton relay proton shuttle (general acid/base) radical combinant radical stabiliser repulsive charge-charge interaction single electron acceptor single electron donor single electron relay single electron shuttle steric hindrance steric locator steric role transition state destabiliser transition state stabiliser unknown van der waals interaction
Unique by Enzyme:
Only Three Star Mechanisms:
Amino Acid:	Ala Cys Asp Glu Phe Gly His Ile Lys Leu Met Asn Pro Gln Arg Ser Thr Val Trp Tyr
Function Location:	Side Chain Post-Translation Modification Main Chain Amine Main Chain Carbonyl Main Chain C-terminus Main Chain N-terminus Main Chain
Function Type:	Interaction Reactant Spectator
Function:	activator alter redox potential attractive charge-charge interaction covalent catalysis covalently attached decrease redox potential electrofuge electron pair acceptor electron pair donor electron pair relay electron pair shuttle electron shuttle electron tunneling medium electrophile electrostatic destabiliser electrostatic interaction electrostatic stabiliser enhance reactivity ground state destabiliser hydride acceptor hydride donor hydride relay hydride shuttle hydrogen bond acceptor hydrogen bond donor hydrogen radical acceptor hydrogen radical donor hydrogen radical relay hydrogen radical shuttle hydrophobic interaction increase acidity increase basicity increase electrophilicity increase nucleophilicity increase redox potential leaving group (radical) metal ligand modifies pKa nucleofuge nucleophile pi-pi interaction polar interaction polar/non-polar interaction promote heterolysis promote homolysis proton acceptor proton donor proton relay proton shuttle (general acid/base) radical combinant radical stabiliser repulsive charge-charge interaction single electron acceptor single electron donor single electron relay single electron shuttle steric hindrance steric locator steric role transition state destabiliser transition state stabiliser unknown van der waals interaction
Only Three Star Mechanisms:
Unique Residue by Role:
Experimental:
Experimental:
Homologues Function:	Same Enzyme Other Substrate Other Reaction NonEnzymes
Homologues Function:	Same Enzyme Other Substrate Other Reaction NonEnzymes

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