M-CSA Mechanism and Catalytic Site Atlas

4-hydroxybutanoyl-CoA dehydratase (M-CSA:750)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P55792

Reference Sequence	Homologue	Tyr296 Glu455 Glu257 Thr190 Cys103 Cys299 Cys99 His292
P55792	P55792	Tyr296 Glu455 Glu257 Thr190 Cys103 Cys299 Cys99 His292
P55792	O30372	not aligned Tyr448 Asp256 Thr189 Thr107 not aligned Phe103 Ile299
P55792	Q5SJP8	not aligned Tyr437 Asp247 Thr185 Ser101 not aligned Met97 Ala290
P55792	C0SPC0	not aligned Tyr445 Asp255 Thr193 Ser105 not aligned Met101 Ile298
P55792	Q9HWT7	not aligned Tyr457 Asp264 Thr196 Thr114 not aligned Trp110 Thr307
P55792	O87009	not aligned Phe442 Asp253 Thr192 Leu101 not aligned Ser97 Ile294
P55792	Q4L1M7	not aligned Tyr448 Asp257 Thr192 Ser104 not aligned Met100 Ala300
P55792	A4IT51	not aligned Tyr450 Asp258 Thr194 Thr106 not aligned Leu102 Val301
P55792	Q8RQQ0	not aligned Tyr459 Asp267 Thr202 Ser120 not aligned Trp116 Ala309
P55792	Q6F4M8	not aligned Phe446 Asp257 Thr194 Pro101 not aligned Ile97 Ile298
P55792	Q57160	not aligned Tyr457 Asp264 Thr196 Thr114 not aligned Trp110 Val307
P55792	Q48440	not aligned Tyr457 Asp264 Thr196 Thr114 not aligned Trp110 Val307