M-CSA Mechanism and Catalytic Site Atlas

Protein-tyrosine-phosphatase non-receptor type 1 (M-CSA:469)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P18031

Reference Sequence	Homologue	Gln262 Asp181 Cys215 Arg221 Ser222
P18031	P18031	Gln262 Asp181 Cys215 Arg221 Ser222
P18031	A4IFW2	Gln1594 Asp1518 Cys1550 Arg1556 Thr1557
P18031	A7MBJ4	Gln1583 Asp1507 Cys1539 Arg1545 Thr1546
P18031	F1NWE3	Gln1201 Asp1125 Cys1157 Arg1163 Thr1164
P18031	A2A8L5	Gln1583 Asp1507 Cys1539 Arg1545 Thr1546
P18031	P18433	Gln486 Asp410 Cys442 Arg448 Thr449
P18031	B2GV87	Gln378 Asp302 Cys334 Arg340 Thr341
P18031	Q13332	Gln1633 Asp1557 Cys1589 Arg1595 Thr1596
P18031	P10586	Gln1592 Asp1516 Cys1548 Arg1554 Thr1555
P18031	Q4JDL3	Gln397 Asp323 Cys353 Arg359 Thr360
P18031	Q64605	Gln1592 Asp1516 Cys1548 Arg1554 Thr1555
P18031	Q64487	Gln1597 Asp1521 Cys1553 Arg1559 Thr1560
P18031	B0V2N1	Gln1592 Asp1516 Cys1548 Arg1554 Thr1555
P18031	P23468	Gln1597 Asp1521 Cys1553 Arg1559 Thr1560
P18031	Q64604	Gln1583 Asp1507 Cys1539 Arg1545 Thr1546
P18031	Q03348	Gln480 Asp404 Cys436 Arg442 Thr443
P18031	P18052	Gln513 Asp437 Cys469 Arg475 Thr476
P18031	P49446	Gln378 Asp302 Cys334 Arg340 Thr341
P18031	P23469	Gln379 Asp303 Cys335 Arg341 Thr342
P18031	Q98936	Gln1081 Asp1005 Cys1037 Arg1043 Thr1044
P18031	Q62656	Gln1978 Asp1902 Cys1934 Arg1940 Thr1941
P18031	Q05909	Gln1101 Asp1025 Cys1057 Arg1063 Thr1064
P18031	P23471	Gln1977 Asp1901 Cys1933 Arg1939 Thr1940
P18031	B9EKR1	Gln1974 Asp1898 Cys1930 Arg1936 Thr1937
P18031	P23470	Gln1104 Asp1028 Cys1060 Arg1066 Thr1067
P18031	O88488	Gln2247 Glu2171 Cys2203 Arg2209 Thr2210
P18031	P0C5E4	Gln2245 Glu2169 Cys2201 Arg2207 Thr2208
P18031	Q9UMZ3	Gln2277 Glu2201 Cys2233 Arg2239 Thr2240
P18031	P16621	Gln1714 Asp1638 Cys1670 Arg1676 Thr1677
P18031	Q62728	Gln1153 Glu1068 Cys1109 Arg1115 Thr1116
P18031	B1AUH1	Gln1129 Glu1053 Cys1085 Arg1091 Thr1092
P18031	Q9WU22	Gln896 Asp820 Cys852 Arg858 Thr859
P18031	Q99M80	Gln1141 Asp1065 Cys1097 Arg1103 Thr1104
P18031	Q06124	Gln510 Asp429 Cys463 Arg469 Thr470
P18031	Q90687	Gln506 Asp425 Cys459 Arg465 Thr466
P18031	P29074	Gln896 Asp820 Cys852 Arg858 Thr859
P18031	P26045	Gln886 Asp811 Cys842 Arg848 Thr849
P18031	O13016	Gln262 Asp181 Cys215 Arg221 Ser222
P18031	Q12913	Gln1283 Asp1205 Cys1239 Arg1245 Thr1246
P18031	P29351	Gln500 Asp419 Cys453 Arg459 Thr460
P18031	O14522	Gln1128 Asp1052 Cys1084 Arg1090 Thr1091
P18031	P23467	Gln1948 Asp1870 Cys1904 Arg1910 Thr1911
P18031	Q9HD43	Gln1064 Asp986 Cys1020 Arg1026 Thr1027
P18031	Q9Y2R2	Gln274 Asp195 Cys227 Arg233 Thr234
P18031	G5EGJ9	Gln1319 Asp1241 Cys1275 Arg1281 Ser1282
P18031	P43378	Gln559 Asp470 Cys515 Arg521 Thr522
P18031	P35822	Gln1144 Asp1068 Cys1100 Arg1106 Thr1107
P18031	O55082	Gln403 Asp329 Cys359 Arg365 Thr366
P18031	P35992	Gln1512 Asp1436 Cys1468 Arg1474 Ser1475
P18031	P06800	Gln884 Asp808 Cys840 Arg846 Thr847
P18031	B3DK56	Gln1127 Glu1051 Cys1083 Arg1089 Thr1090
P18031	B2RU80	Gln1949 Asp1871 Cys1905 Arg1911 Thr1912
P18031	Q15262	Gln1126 Asp1050 Cys1082 Arg1088 Thr1089
P18031	P35821	Gln262 Asp181 Cys215 Arg221 Ser222
P18031	Q9W0G1	Gln281 Asp203 Cys237 Arg243 Ser244
P18031	P17706	Gln260 Asp182 Cys216 Arg222 Ser223
P18031	P29350	Gln500 Asp419 Cys453 Arg459 Thr460
P18031	P29352	Gln274 Asp195 Cys227 Arg233 Thr234
P18031	Q92729	Gln1129 Glu1053 Cys1085 Arg1091 Thr1092
P18031	A2ALK8	Gln886 Asp811 Cys842 Arg848 Thr849
P18031	P34138	Gln332 Asp251 Cys281 Arg287 Ser288
P18031	Q16827	Gln1180 Asp1102 Cys1136 Arg1142 Thr1143
P18031	H2KZM6	Gln1057 Asp981 Cys1013 Arg1019 Thr1020
P18031	Q641Z2	Gln559 Asp470 Cys515 Arg521 Thr522
P18031	P28827	Gln1139 Asp1063 Cys1095 Arg1101 Thr1102
P18031	P35233	Gln260 Asp182 Cys216 Arg222 Ser223
P18031	O35239	Gln559 Asp470 Cys515 Arg521 Thr522
P18031	P81718	Gln502 Asp421 Cys455 Arg461 Thr462
P18031	P08575	Gln895 Asp819 Cys851 Arg857 Thr858
P18031	P16620	Gln1141 Asp1065 Cys1097 Arg1103 Thr1104
P18031	Q6YI48	Gln1117 Glu1041 Cys1073 Arg1079 Thr1080
P18031	E9Q0N2	Gln915 Asp837 Cys871 Arg877 Thr878
P18031	Q64455	Gln1184 Asp1106 Cys1140 Arg1146 Thr1147
P18031	P35832	Gln726 Asp650 Cys682 Arg688 Thr689
P18031	Q05209	Gln278 Asp199 Cys231 Arg237 Thr238
P18031	E9Q612	Gln1190 Asp1112 Cys1146 Arg1152 Thr1153
P18031	Q06180	Gln260 Asp182 Cys216 Arg222 Ser223
P18031	Q9W6V5	Gln1352 Asp1274 Cys1308 Arg1314 Thr1315
P18031	A1L1L3	Gln398 Asp324 Cys354 Arg360 Thr361
P18031	P29349	Gln630 Asp545 Cys583 Arg589 Thr590
P18031	P41499	Gln510 Asp429 Cys463 Arg469 Thr470
P18031	P28828	Gln1139 Asp1063 Cys1095 Arg1101 Thr1102
P18031	Q12923	Gln2452 Asp2378 Cys2408 Arg2414 Ser2415
P18031	P20417	Gln262 Asp181 Cys215 Arg221 Ser222
P18031	P35235	Gln510 Asp429 Cys463 Arg469 Thr470
P18031	P04157	Gln866 Asp790 Cys822 Arg828 Thr829
P18031	Q5I137	Gln275 Asp189 Cys230 Phe234 Asn236
P18031	Q15678	Gln1165 Asp1079 Cys1121 Arg1127 Thr1128
P18031	P28191	Gln996 Asp920 Cys952 Arg958 Thr959
P18031	P80560	Gln976 Asp899 Cys931 Arg937 Ser938
P18031	G5EGU2	Leu294 Glu196 Cys248 Arg254 Cys255
P18031	O88902	Gln1300 Glu1220 Cys1255 Arg1261 Thr1262
P18031	Q9H3S7	Gln1437 Glu1357 Cys1392 Arg1398 Thr1399
P18031	Q15256	Gln632 Asp554 Cys588 Arg594 Thr595
P18031	P56722	Arg954 Ala877 Cys909 Arg915 Thr916
P18031	P28192	Gln888 Asp814 Cys844 Arg850 Ser851
P18031	Q5I143	not aligned Asp103 Cys142 Arg148 Thr149
P18031	Q5I141	Ser279 Gln192 Ser235 Arg241 Ala242
P18031	Q5I127	His93 not aligned Thr71 Asp77 Lys78
P18031	O82656	Gln311 Asp234 Cys265 Arg271 Thr272
P18031	Q60673	Arg954 Ala877 Cys909 Arg915 Thr916
P18031	G5EGJ5	Ala741 Lys664 Ser696 Arg702 Thr703
P18031	P32586	Gln683 Asp601 Cys630 Arg636 Thr637
P18031	P35234	Gln344 Asp265 Cys300 Arg306 Thr307
P18031	Q64612	Gln1394 Asp1316 Cys1350 Arg1356 Thr1357
P18031	P35831	Gln278 Asp199 Cys231 Arg237 Thr238
P18031	P34137	Gln456 Asp272 Cys310 Arg316 Thr317
P18031	Q5I145	Phe294 Asp211 Cys250 Arg256 Thr257
P18031	Q5I146	Phe280 Asp190 Cys236 Arg242 Thr243
P18031	Q8BUM3	Gln334 Asp257 Cys290 Arg296 Thr297
P18031	P49445	Gln334 Asp257 Cys290 Arg296 Thr297
P18031	P27574	Gln524 Asp440 Cys470 Arg476 Thr477
P18031	P70289	Gln1394 Asp1316 Cys1350 Arg1356 Thr1357
P18031	Q62130	Gln1167 His1081 Cys1123 Arg1129 Thr1130
P18031	P54830	Gln516 Asp437 Cys472 Arg478 Thr479
P18031	Q64512	Gln2419 Asp2345 Cys2375 Arg2381 Ser2382
P18031	Q5I128	Ser277 not aligned Cys233 Lys239 Thr240
P18031	O08617	Gln631 Asp553 Cys587 Arg593 Thr594
P18031	Q16849	Arg954 Ala877 Cys909 Arg915 Thr916
P18031	P35236	Gln335 Asp257 Cys291 Arg297 Thr298
P18031	P54829	Gln540 Asp461 Cys496 Arg502 Thr503
P18031	P54637	Gln700 Asp613 Cys650 Arg656 Ser657
P18031	Q5I142	not aligned Asp210 Ala249 not aligned not aligned
P18031	P25044	Gln313 Asp221 Cys252 Arg258 Thr259
P18031	P32587	Gln277 Asp193 Cys227 Arg233 Thr234
P18031	Q92932	Gln990 Asp913 Cys945 Arg951 Ser952
P18031	Q61152	Gln276 Asp197 Cys229 Arg235 Thr236
P18031	Q99952	Gln276 Asp197 Cys229 Arg235 Thr236
P18031	Q62136	Gln1154 Glu1069 Cys1110 Arg1116 Thr1117
P18031	Q16825	Gln1152 Glu1067 Cys1108 Arg1114 Thr1115
P18031	G5EC24	Gln565 Asp476 Cys518 Arg524 Thr525
P18031	Q63475	Gln979 Asp902 Cys934 Arg940 Ser941
P18031	Q6PB44	Gln1493 Glu1413 Cys1448 Arg1454 Thr1455
P18031	Q63259	Arg958 Ala881 Cys913 Arg919 Thr920
P18031	Q62132	Gln631 Asp553 Cys587 Arg593 Thr594
P18031	Q5I147	Met280 His199 Cys236 Trp242 Thr243
P18031	Q5I138	not aligned Tyr187 not aligned Arg217 Thr219
P18031	Q5I139	Arg272 Asp188 Cys227 Asn231 Ser233
P18031	P29461	Gln722 Asp605 Cys666 Arg672 Thr673
P18031	P28198	not aligned Asp76 not aligned not aligned not aligned
P18031	Q8ISC9	Gln340 Asp255 Cys293 Arg299 Thr300
P18031	P28195	not aligned Asp80 not aligned not aligned not aligned
P18031	P28202	not aligned Asp86 not aligned not aligned not aligned
P18031	Q9BMN8	Gln1887 Asp1811 Cys1843 Arg1849 Thr1850
P18031	O02695	Gln988 Asp911 Cys943 Arg949 Ser950
P18031	P28204	not aligned Asp84 not aligned not aligned not aligned
P18031	P28201	not aligned Asp81 not aligned not aligned not aligned
P18031	P28209	Ser102 Asp82 not aligned not aligned Ser90
P18031	P28199	not aligned Asp82 not aligned not aligned not aligned
P18031	Q9IBD8	Gln804 Asp728 Cys760 Arg766 Thr767
P18031	P28206	not aligned Asp84 not aligned not aligned not aligned
P18031	P28205	not aligned not aligned not aligned not aligned not aligned
P18031	P28203	not aligned Asp81 not aligned not aligned not aligned
P18031	Q24708	Gln507 Asp422 Cys460 Arg466 Thr467