M-CSA Mechanism and Catalytic Site Atlas

Cellulose 1,4-beta-cellobiosidase (non-reducing end) (M-CSA:440)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P07987

Reference Sequence	Homologue	Tyr193 Arg198 Asp199 Asp245 Asp425 Ser205
P07987	P07987	Tyr193 Arg198 Asp199 Asp245 Asp425 Ser205
P07987	P26222	Tyr104 Arg109 Asp110 Asp148 Asp296 Ser115
P07987	Q9C1S9	Tyr200 Arg205 Asp206 Asp252 Asp431 Ser212
P07987	G0RV93	Phe177 not aligned not aligned His240 Asp453 Gly187
P07987	A1C8U0	Leu184 Ser189 not aligned Arg263 Ala410 Lys193
P07987	A1DJQ7	Tyr174 Arg179 Asp180 Asp226 Asp405 Ser186
P07987	B2ABS0	Phe189 not aligned not aligned His254 Pro474 Gly199
P07987	G4MM92	Tyr210 Arg215 Asp216 Asp262 Asp441 Ser222
P07987	Q0CFP1	Tyr192 Arg197 Asp198 Asp244 Asp423 Ser204
P07987	B2ADA5	Tyr109 Arg114 Asp115 Asp162 Asp334 Ser121
P07987	B2AC20	Tyr146 Arg151 Asp152 Asp199 Asp381 Ser158
P07987	Q7SDR1	Leu158 Asn163 Ser164 Asn219 Gly364 Gly169
P07987	Q5B2E8	Tyr179 Arg184 Asp185 Asp231 Asp410 Ser191
P07987	B2ABX7	Tyr208 Arg213 Asp214 Asp260 Asp439 Ser220
P07987	Q5AR04	Leu178 Ser183 not aligned Arg258 Gln404 Lys187
P07987	A1CCN4	Tyr188 Arg193 Asp194 Asp240 Asp419 Ser200
P07987	Q9P7F1	not aligned not aligned not aligned Ser142 not aligned not aligned
P07987	P50401	Tyr133 Arg138 Asp139 Asp188 Asp410 Ser145
P07987	Q4WFK4	Tyr178 Arg183 Asp184 Asp230 Asp409 Ser190
P07987	B2AE04	Tyr119 Arg124 Asp125 Asp170 Asp352 Ser131
P07987	P07982	Tyr176 Gln181 Gly182 His241 Asp389 Gly187
P07987	Q7SIG5	Tyr86 Arg91 Asp92 Asp139 Asp316 Ser98
P07987	Q9HEZ1	not aligned Asn161 not aligned not aligned Gln383 Ser165
P07987	P50272	Tyr70 not aligned Gln72 not aligned Met182 not aligned
P07987	A2QYR9	Tyr183 Arg188 Asp189 Asp235 Asp414 Ser195
P07987	B7SIW2	not aligned Thr151 not aligned not aligned Gln374 Thr155
P07987	P46236	Tyr184 Arg189 Asp190 Asp236 Asp416 Ser196
P07987	P49075	Tyr163 Arg168 Asp169 Asp215 Asp404 Ala174
P07987	A0A024SH20	Tyr176 Gln181 Gly182 His241 Asp389 Gly187
P07987	B0XWL3	Tyr178 Arg183 Asp184 Asp230 Asp409 Ser190
P07987	A0A024SH76	Tyr193 Arg198 Asp199 Asp245 Asp425 Ser205