M-CSA Mechanism and Catalytic Site Atlas

Beta-galactosidase (M-CSA:422)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P00722

Reference Sequence	Homologue	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 (main-C) Asn605 Asn598
P00722	P00722	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	P08236	His351 Glu451 Glu540 His385 Gly409 Asp207 not aligned Lys605 not aligned Arg600
P00722	A7MN76	His367 Glu471 Glu547 His401 Glu426 Asp212 His428 Phe611 Asn614 Asn607
P00722	A9MQ82	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	B2VHN8	His359 Glu463 Glu539 His393 Glu418 Asp203 His420 Phe603 Asn606 Asn599
P00722	A6TI29	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	Q04F24	His353 Glu457 Glu533 His387 Glu412 Asp197 His414 Phe597 Asp600 Asn593
P00722	P00723	His355 Glu482 Glu551 His389 Glu414 Asp187 His416 Phe620 Asp623 His616
P00722	A6T8X0	His365 Glu469 Glu545 His399 Glu424 Asp208 His426 Phe609 Asn612 Asn605
P00722	Q4FAT7	His351 Glu451 Glu540 His385 Gly409 Asp207 not aligned Arg605 not aligned Arg600
P00722	A8AKB8	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	Q7CIZ3	His373 Glu477 Glu553 His407 Glu432 Asp209 His434 Phe617 Asn620 Asn613
P00722	P06760	His347 Glu447 Glu536 His381 Gly405 Asp206 not aligned Lys601 not aligned Arg596
P00722	O97524	His350 Glu450 Glu539 His384 Gly408 Asp206 not aligned Lys604 not aligned Arg599
P00722	A4W7D2	His359 Glu463 Glu539 His393 Glu418 Asp203 His420 Phe603 Asn606 Asn599
P00722	P06864	His342 Glu449 Glu512 His376 Glu401 Asp190 His403 Phe576 Asp579 Asn572
P00722	A8GGN3	His357 Glu461 Glu537 His391 Glu416 Asp203 His418 Phe601 Asn604 Asn597
P00722	Q32JB6	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	A0KQH4	His358 Glu462 Glu538 His392 Glu417 Asp204 His419 Phe602 Asn605 Asn598
P00722	P12265	His347 Glu447 Glu536 His381 Gly405 Asp206 not aligned Lys601 not aligned Arg596
P00722	Q9K9C6	His348 Glu460 Glu527 His382 Glu407 Asp201 His409 Phe591 Asn594 Thr587
P00722	Q03WL0	His352 Glu456 Glu532 His386 Glu411 Asp197 His413 Phe596 Asp599 Asn592
P00722	Q56307	His335 Glu441 Glu507 His369 Glu394 Asp191 His396 Phe571 Asn574 Asn567
P00722	P05804	His296 Glu413 Glu504 His330 Ala354 Asp163 not aligned Lys567 not aligned Arg562
P00722	A1SWB8	His356 Glu460 Glu540 His390 Glu415 Asp199 His417 Phe604 Asn607 Asn600
P00722	Q5R5N6	His351 Glu451 Glu540 His385 Gly409 Asp207 not aligned Lys605 not aligned Arg600
P00722	Q6D736	His368 Glu472 Glu548 His402 Glu427 Asp210 His429 Phe612 Asp615 Asn608
P00722	P77989	His290 Glu388 Glu453 His325 Gln351 Asp142 not aligned Tyr515 not aligned Asn512
P00722	O07684	His356 Glu468 Glu536 His390 Glu415 Asp210 His417 Phe601 Asp604 Ser597
P00722	Q48727	His327 Glu431 Glu508 His361 Glu386 Asp189 His388 Phe567 Asn570 Asn563
P00722	Q6LL68	His352 Glu456 Glu532 His386 Glu411 Asp197 His413 Phe596 Asn599 Asn592
P00722	O18835	His350 Glu450 Glu539 His384 Gly408 Asp206 not aligned Arg604 not aligned Arg599
P00722	Q7MG04	His353 Glu457 Glu533 His387 Glu412 Asp198 His414 Phe597 Asn600 Asn593
P00722	Q1G9Z4	His352 Glu465 Glu532 His386 Glu411 Asp207 His413 Phe590 Asn593 Thr586
P00722	Q8VNN2	His363 Glu467 Glu543 His397 Glu422 Asp207 His424 Phe607 Asn610 Asn603
P00722	A7FH78	His373 Glu477 Glu553 His407 Glu432 Asp209 His434 Phe617 Asn620 Asn613
P00722	A7ZWZ1	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	Q7WTB4	His356 Glu468 Glu536 His390 Glu415 Asp210 His417 Phe601 Asp604 Ser597
P00722	P0C1Y0	His352 Glu465 Glu532 His386 Glu411 Asp207 His413 Phe590 Asn593 Thr586
P00722	Q0TKT1	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	P26257	His291 Glu389 Glu462 His326 Gln352 Asp140 not aligned Tyr524 not aligned Arg521
P00722	P06219	His364 Glu468 Glu544 His398 Glu423 Asp207 His425 Phe608 Asn611 Asn604
P00722	A3FEW8	His359 Glu463 Glu539 His393 Glu418 Asp203 His420 Phe603 Asn606 Asn599
P00722	O33815	His324 Glu437 Glu510 His358 Glu383 Asp191 His385 Phe574 Asp577 His570
P00722	A1A831	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	Q8D4H3	His354 Glu458 Glu534 His388 Glu413 Asp198 His415 Phe598 Asn601 Asn594
P00722	B1J0T5	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	Q1RFJ2	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	P23989	His346 Glu458 Glu546 His380 Glu405 Asp201 His407 Phe609 Asn612 Ser605
P00722	Q59140	His327 Glu434 Glu513 His361 Glu386 Asp198 His388 Phe577 Asp580 His573
P00722	B7N8Q1	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	B2K6E6	His373 Glu477 Glu553 His407 Glu432 Asp209 His434 Phe617 Asn620 Asn613
P00722	B4S2K9	His356 Glu460 Glu536 His390 Glu415 Asp201 His417 Phe600 Asn603 Asn596
P00722	B5XQY2	His365 Glu469 Glu545 His399 Glu424 Asp208 His426 Phe609 Asn612 Asn605
P00722	B7UJI9	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	A9R0J8	His363 Glu467 Glu543 His397 Glu422 Asp199 His424 Phe607 Asn610 Asn603
P00722	Q2XQU3	Leu359 Glu463 Glu539 His393 Glu418 Asp203 His420 Phe603 Asn606 Asn599
P00722	A1JTC4	His373 Glu477 Glu553 His407 Glu432 Asp209 His434 Phe617 Asn620 Asn613
P00722	O77695	His348 Glu448 Glu537 His382 Gly406 Asp204 not aligned Lys602 not aligned Arg597
P00722	Q48846	His353 Glu465 Glu533 His387 Glu412 Asp210 His414 Phe598 Asp601 Ser594
P00722	B5Z2P7	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	Q8X685	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	Q47077	His359 Glu463 Glu539 His393 Glu418 Asp203 His420 Phe603 Asn606 Asn599
P00722	P81650	His356 Glu460 Glu536 His390 Glu415 Asp201 His417 Phe600 Asn603 Asn596
P00722	P24131	His347 Glu459 Glu525 His381 Glu406 Asp202 His408 Phe589 Asn592 Thr585
P00722	Q8FKG6	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	A7ZI91	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	A7KGA5	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	P70753	His321 Glu455 Glu526 His355 Glu380 Asp189 His382 Phe586 Asp589 His582
P00722	Q1C6T8	His373 Glu477 Glu553 His407 Glu432 Asp209 His434 Phe617 Asn620 Asn613
P00722	B1LIM9	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	A7LXS9	His335 Glu437 Glu544 His369 Arg396 Arg180 His402 Tyr633 not aligned Arg630
P00722	Q02603	His354 Glu466 Glu534 His388 Glu413 Asp209 His415 Phe599 Asn602 Ser595
P00722	A5F5U6	His355 Glu459 Glu535 His389 Glu414 Asp198 His416 Phe599 Asn602 Asn595
P00722	O52847	His369 Glu481 Glu547 His404 Glu429 Asp214 His431 Phe611 Asn614 Asn607
P00722	Q3Z583	His358 Glu462 Glu538 His392 Glu417 Asp202 His419 Phe602 Asn605 Asn598
P00722	Q1CI76	His373 Glu477 Glu553 His407 Glu432 Asp209 His434 Phe617 Asn620 Asn613
P00722	Q669R9	His373 Glu477 Glu553 His407 Glu432 Asp209 His434 Phe617 Asn620 Asn613
P00722	A4TLL5	His373 Glu477 Glu553 His407 Glu432 Asp209 His434 Phe617 Asn620 Asn613
P00722	B1JI86	His373 Glu477 Glu553 His407 Glu432 Asp209 His434 Phe617 Asn620 Asn613