M-CSA Mechanism and Catalytic Site Atlas

Chloromuconate cycloisomerase (M-CSA:348)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P05404

Reference Sequence	Homologue	Asp194 Glu220 Lys269 Lys165 Glu323 Asp245 Lys163
P05404	P08310	Asp200 Glu226 Lys275 Lys171 Glu329 Asp251 Lys169
P05404	P05404	Asp194 Glu220 Lys269 Lys165 Glu323 Asp245 Lys163
P05404	P11452	Asp194 Glu220 Lys269 Lys165 Glu323 Asp245 Lys163
P05404	A9CEQ8	Asp194 Glu220 Asp269 Lys166 not aligned Gly245 Lys164
P05404	O06741	Asp187 Glu214 Asp263 Lys158 Lys315 Gly239 Lys156
P05404	Q607C7	Asp190 Glu216 Lys266 Lys162 Asp319 Asp241 Lys160
P05404	Q834W6	Asp189 Glu215 Lys264 Lys161 Asp318 Asp240 Lys159
P05404	Q81IL5	Asp191 Glu218 Lys267 Lys163 Glu320 Asp243 Lys161
P05404	A8G7R4	Asp183 Glu209 Asp258 Asn146 Glu310 Gly234 Lys144
P05404	Q8ZL58	Asp226 Glu252 Asp301 Lys197 Glu348 Gly277 Lys195
P05404	Q97U96	Asp199 Glu225 Asp274 Lys170 not aligned Tyr250 Lys168
P05404	B2UCA8	Asp183 Glu209 Asp258 Asn146 Glu310 Gly234 Lys144
P05404	Q6CYT9	Asp183 Glu209 Asp258 Asn146 Glu310 Gly234 Lys144
P05404	Q43931	Asp195 Glu221 Lys270 Lys166 Glu324 Asp246 Lys164
P05404	O34508	Asp191 Glu219 Lys268 Lys162 Asp321 Asp244 Lys160
P05404	Q97MK4	Asp190 Glu218 Lys267 Lys162 Asp320 Asp243 Lys160
P05404	D4GP40	Asp230 Glu256 Asp305 Asp186 Glu357 Gly281 Lys184
P05404	Q11T61	Asp190 Glu216 Lys265 Lys162 Asp318 Asp241 Lys160
P05404	A4W7D6	Asp205 Glu231 His280 Gln153 not aligned Gly256 Arg151
P05404	O34514	Asp189 Glu214 Lys263 Lys164 Asp316 Asp239 Lys162
P05404	B9I2J6	Asp247 Glu275 Lys328 Lys220 Asp380 Asp304 Lys218
P05404	A9B055	Asp191 Glu219 Lys268 Lys163 Asp320 Asp244 Lys161
P05404	A1WPC7	Asp183 Glu209 Asp258 Asn146 Glu310 Gly234 Lys144
P05404	Q30PM2	Asp186 Glu212 Lys261 Lys159 Asp315 Asp237 Lys157
P05404	Q0FPQ4	Asp193 Glu218 Lys265 Lys163 Arg314 Asp241 Gln161
P05404	B9XEK4	Asp183 Glu211 Lys259 Lys158 Asp309 Asp237 Lys156
P05404	C0QM06	Asp190 Glu215 Lys265 Lys162 Asp318 Asp240 Lys160
P05404	B5EFW2	Asp197 Glu225 Lys277 Lys170 Asp329 Asp253 Lys168
P05404	A1B198	Asp194 Glu219 Lys266 Lys164 Arg315 Asp242 Gln162
P05404	C6CVY9	Asp208 Glu234 Arg283 Gln151 not aligned Gly259 Arg149
P05404	Q9WXM1	Asp188 Glu216 Lys265 Lys161 Asp317 Asp241 Lys159
P05404	Q8A861	Asp224 Glu251 Lys298 Lys200 Asp348 Asp276 Lys198
P05404	A0NXQ8	Asp193 Glu218 Lys265 Lys165 Glu314 Asp241 Gln163
P05404	B0TZW0	Asp191 Glu219 Lys268 Lys163 Asp320 Asp244 Lys161
P05404	P27099	Asp194 Glu220 Lys269 Lys165 Glu323 Asp245 Lys163
P05404	P42428	Asp187 Glu213 Lys262 Lys158 Glu316 Asp238 Lys156
P05404	O33946	Asp198 Glu224 Lys271 Lys169 Glu325 Asp247 Lys167
P05404	F7ZLS5	Asp184 Glu210 Lys257 Lys153 Asp307 Asp235 Lys151
P05404	P95608	Asp198 Glu224 Lys273 Lys169 Glu327 Asp249 Lys167
P05404	A0Q5S7	Asp191 Glu219 Lys268 Lys163 Asp320 Asp244 Lys161
P05404	P83763	Asp194 Glu220 Lys269 Lys165 Glu323 Asp245 Lys163
P05404	Q704D2	Glu303 Glu329 Asp378 Asp266 Glu430 Gly354 Lys264
P05404	Q9RNZ9	Asp194 Glu220 Lys269 Lys165 Glu323 Asp245 Lys163
P05404	C9Y5D5	Asp205 Glu231 His280 Gln153 not aligned Gly256 Arg151
P05404	O33949	Asp200 Glu226 Lys275 Lys171 Glu329 Asp251 Lys169