M-CSA Mechanism and Catalytic Site Atlas

Beta-ketoacyl-[acyl carrier protein] synthase I (M-CSA:292)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P0A953

Reference Sequence	Homologue	Lys328 His333 Phe390 (main-C) Phe392 (main-N) Cys163 His298
P0A953	P0A953	Lys328 His333 Phe390 Phe392 Cys163 His298
P0A953	P0AAI5	Lys336 His341 Phe399 Phe401 Cys164 His304
P0A953	P40806	Lys3690 His3695 Phe4217 not aligned Cys3511 His3646
P0A953	O31782	Lys2923 His2928 Lys3239 not aligned Cys2747 His2882
P0A953	E9F8M3	Lys955 His960 Phe1402 Phe1417 Cys785 His920
P0A953	D4AU31	Lys963 His968 Phe1410 Phe1425 Cys793 His928
P0A953	Q0D159	Lys353 His358 Phe816 Val833 Cys177 His314
P0A953	Q5ATG8	Lys356 His361 Phe822 Ala839 Cys176 His313
P0A953	W7MLD7	Lys355 His360 Tyr780 Phe812 Cys182 His319
P0A953	S0EEY3	Lys355 His360 Tyr780 Phe812 Cys182 His319
P0A953	B8NJG3	Lys358 His363 Phe819 Val836 Cys183 His320
P0A953	P9WQE1	Lys356 His361 Phe797 Leu812 Cys184 His320
P0A953	A0A098D6U0	Lys706 His711 Phe1139 Trp1155 Cys537 His672
P0A953	P9WQE5	Lys372 His377 Phe807 Phe825 Cys205 His340
P0A953	A1D8I9	Lys735 His740 Phe1181 Trp1200 Cys562 His697
P0A953	P9WQE3	Lys378 His383 Phe810 Phe824 Cys207 His342
P0A953	S3D9F1	Lys353 His358 Phe855 Phe872 Cys187 His322
P0A953	Q0C9L7	Lys279 His284 Phe743 Ile759 Cys105 His244
P0A953	B0G0Z9	Lys357 His362 Phe803 Phe825 Cys181 His323
P0A953	B8N8R0	Lys725 His730 Phe1160 Trp1179 Cys554 His689
P0A953	Q54FQ3	Lys379 His384 Phe832 Phe854 Cys200 His339
P0A953	Q86JI5	Lys363 His368 Phe806 Phe828 Cys187 His329
P0A953	B0G100	Lys357 His362 Phe800 Phe822 Cys181 His323
P0A953	Q0D1N9	Lys662 His667 Phe1097 Trp1116 Cys488 His623
P0A953	Q54FN7	Lys375 His380 Phe831 Phe853 Cys196 His335
P0A953	Q55DM7	Lys348 His353 Phe800 Phe822 Cys174 His313
P0A953	I1RVD8	Lys402 His407 Phe856 Leu876 Cys230 His367
P0A953	Q4W944	Lys735 His740 Phe1172 Trp1191 Cys564 His699
P0A953	G1XU04	Lys362 His367 Leu803 Phe818 Cys190 His325
P0A953	G4N296	Lys393 His398 Phe879 Leu895 Cys224 His359
P0A953	M2XHZ5	Lys717 His722 Met1155 Val1174 Cys544 His679
P0A953	B0G170	Lys361 His366 Phe822 Phe844 Cys187 His326
P0A953	S0EET5	Lys378 His383 Phe839 not aligned Cys202 His341
P0A953	Q5BA83	Lys391 His396 Phe847 Leu867 Cys222 His356
P0A953	Q54FD2	Lys358 His363 Phe818 Phe840 Cys181 His320
P0A953	Q0C8M3	Lys362 His367 Phe828 Gly845 Cys181 His320
P0A953	W7LKX1	Lys369 His374 Phe861 Phe881 Cys201 His336
P0A953	A0A179H0J7	Lys383 His388 Phe705 not aligned Cys217 His353
P0A953	Q54FQ2	Lys376 His381 Phe834 Phe856 Cys198 His337
P0A953	Q4WLD4	Lys355 His360 Phe810 Ile827 Cys177 His317
P0A953	Q0CCY3	Lys749 His754 Phe1188 Trp1207 Cys575 His711
P0A953	C8VJR7	Lys391 His396 Phe863 Leu894 Cys221 His356
P0A953	Q869W9	Lys351 His356 Phe802 Phe824 Cys179 His316
P0A953	A0A0H4ADX3	Lys735 His740 Phe1171 Trp1190 Cys561 His696
P0A953	A2R6H1	Lys350 His355 Phe831 Phe869 Cys182 His317
P0A953	Q4WA61	Lys735 His740 Phe1181 Trp1200 Cys562 His697
P0A953	Q54KU3	Lys375 His380 Phe817 Phe839 Cys198 His340
P0A953	W7MT31	Lys398 His403 Phe862 Met890 Cys230 His365
P0A953	Q86AE3	Lys357 His362 Phe803 Phe825 Cys181 His323
P0A953	Q5B8A0	Lys690 His695 Phe1132 Trp1148 Cys521 His656
P0A953	A1CFL8	Lys316 His321 Leu754 Phe769 Cys146 His281
P0A953	S0DRI1	Lys398 His403 Phe862 Met890 Cys230 His365
P0A953	Q54ED7	Lys357 His362 Phe797 Phe823 Cys179 His320
P0A953	Q54B51	Lys353 His358 Phe816 Phe838 Cys175 His320
P0A953	O53901	Lys351 His356 Phe794 Phe809 Cys185 His320
P0A953	Q5BEJ4	Lys327 His332 Phe818 Ile838 Cys159 His294
P0A953	A2QX22	Lys734 His739 Phe1179 Trp1198 Cys561 His696
P0A953	A0A089QRB9	Lys344 His349 Phe786 Phe801 Cys178 His313
P0A953	G3XMD1	Lys350 His355 Phe814 Val840 Cys180 His315
P0A953	Q54FN2	Lys380 His385 Phe836 Phe858 Cys200 His339
P0A953	Q54KU5	Lys367 His372 Phe822 Phe844 Cys190 His332
P0A953	P9WQE7	Lys443 His448 Phe878 Phe896 Cys273 His408
P0A953	Q55CN6	Lys383 His388 Phe833 Phe855 Cys209 His348
P0A953	B6HNK3	Lys354 His359 Phe837 Val859 Cys187 His322
P0A953	A0R1E8	Lys344 His349 Phe789 Phe804 Cys178 His313
P0A953	Q4WQZ5	Lys754 His759 Phe1197 Trp1216 Cys580 His716
P0A953	Q54B49	Lys348 His353 Phe831 Phe853 Cys170 His315
P0A953	A0A0N0DCA3	Lys394 His399 Phe852 Leu870 Cys221 His358
P0A953	S0EMV0	Lys353 His358 Tyr827 Cys845 Cys182 His318
P0A953	B8NYX0	Lys348 His353 Leu786 not aligned Cys178 His313
P0A953	Q54FP8	Lys383 His388 Phe835 Phe857 Cys199 His338
P0A953	M1WG96	Lys753 His758 Phe1196 Trp1215 Cys579 His715
P0A953	Q54ED6	Lys355 His360 Phe796 Phe822 Cys177 His318
P0A953	Q5BEJ6	Lys780 His785 Phe1234 Phe1250 Cys611 His746
P0A953	G0R6S9	Lys732 His737 Phe1180 Trp1196 Cys561 His696
P0A953	B0G103	Lys358 His363 Phe804 Ile828 Cys184 His325
P0A953	Q5B0D0	Lys737 His742 Phe1176 Trp1195 Cys564 His699
P0A953	Q869X2	Lys351 His356 Phe802 Phe824 Cys179 His316
P0A953	Q54FQ1	Lys379 His384 Phe837 Phe859 Cys199 His338
P0A953	G0R6S8	Lys354 His359 Phe811 Val832 Cys187 His322
P0A953	B6HN77	Lys767 His772 Phe1217 Trp1233 Cys596 His731
P0A953	Q54G30	Lys360 His365 Phe821 Phe843 Cys183 His322
P0A953	A0A098D8A0	Lys351 His356 Phe800 Leu822 Cys181 His316
P0A953	C5FM57	Lys738 His743 Phe1184 Trp1203 Cys565 His700
P0A953	P9WQE9	Lys362 His367 Phe801 Phe816 Cys196 His331
P0A953	A0A0A2JW91	Lys358 His363 Phe804 Phe832 Cys187 His322
P0A953	Q5AUX1	Lys697 His702 Phe1140 Ala1159 Cys525 His660
P0A953	P96202	Lys379 His384 Phe822 Phe836 Cys210 His345
P0A953	Q5BH30	Lys763 His768 Phe1202 Trp1221 Cys589 His725
P0A953	Q4WAY3	Lys362 His367 Phe841 not aligned Cys188 His327
P0A953	Q54FC8	Lys358 His363 Phe814 Phe836 Cys181 His320
P0A953	A0A0D2YG10	Lys398 His403 Phe862 Met890 Cys230 His365
P0A953	O34340	Lys335 His340 Leu397 Phe399 Cys164 His303
P0A953	P56902	Lys342 His347 Phe404 Phe406 Cys170 His311
P0A953	Q9KQH9	Lys337 His342 Phe400 Phe402 Cys164 His304
P0A953	P43710	Lys327 His332 Phe390 Phe392 Cys162 His297
P0A953	Q83E37	Lys336 His341 Phe398 Phe400 Cys164 His304
P0A953	Q8L3X9	Lys384 His389 Phe447 Phe449 Cys209 His350
P0A953	P57193	Lys330 His335 not aligned not aligned Cys164 His299
P0A953	Q89AY4	Lys330 His335 not aligned not aligned Cys164 His299
P0A953	Q05470	Lys779 His784 Ile1258 Leu1260 Cys609 His744
P0A953	P39525	Lys357 His362 not aligned not aligned Cys187 His322
P0A953	P9WQD9	Lys340 His345 not aligned not aligned Cys171 His311
P0A953	Q9D404	Lys380 His385 Phe445 Phe447 Cys209 His348
P0A953	O69473	Lys344 His349 not aligned not aligned Cys173 His314
P0A953	P06230	Lys326 His331 Phe388 Met390 Cys162 His294
P0A953	P9WQD7	Lys341 His346 not aligned not aligned Cys170 His311
P0A953	O94297	Lys346 His351 Phe410 Phe412 Cys170 His311
P0A953	P73283	Lys339 His344 Phe401 Phe403 Cys167 His307
P0A953	P52410	Lys395 His400 not aligned not aligned Cys224 His364
P0A953	Q02059	Lys384 His389 not aligned Phe448 Cys212 His352
P0A953	Q9CBS7	Lys340 His345 not aligned not aligned Cys171 His311
P0A953	Q9NWU1	Lys380 His385 Phe445 Phe447 Cys209 His348
P0A953	Q9C9P4	Lys463 His468 not aligned not aligned Cys292 His432
P0A953	Q0VCA7	Lys381 His386 Phe446 Phe448 Cys210 His349
P0A953	P40872	Lys739 His744 Val1218 Phe1220 Cys569 His704
P0A953	Q54IX3	Lys351 His356 Phe788 Phe810 Cys174 His316
P0A953	P23155	Lys342 His347 not aligned Phe406 Cys170 His310
P0A953	P40804	Lys333 His338 not aligned not aligned Ser164 His304
P0A953	G3Y419	Lys387 His392 Leu831 Leu846 Cys215 His350
P0A953	Q55E72	Lys375 His380 Phe844 Tyr867 Cys180 His319
P0A953	O31784	Lys1857 His1862 not aligned not aligned Cys1680 His1815
P0A953	Q9HU15	Lys467 His472 not aligned not aligned Cys281 His434
P0A953	Q54T36	Lys352 His357 Phe798 Phe820 Cys176 His315
P0A953	Q559A9	Lys353 His358 Phe790 Phe812 Cys176 His317
P0A953	Q71SP7	Lys326 His331 Phe745 Val758 Cys161 His293
P0A953	Q2HEW5	Lys3313 His3318 Phe3896 Leu3913 Leu1581 His3183
P0A953	G4NEB1	Lys411 His416 Phe975 Leu1006 not aligned His376
P0A953	B0G138	Lys352 His357 Phe801 Phe823 Cys176 His315
P0A953	Q5ATJ7	Lys713 His718 His1097 Phe1099 Cys544 His679
P0A953	Q0C8A4	Lys663 His668 His1008 Phe1010 Cys494 His629
P0A953	P23156	not aligned not aligned not aligned not aligned not aligned not aligned
P0A953	Q0CJ59	Lys386 His391 Leu826 Phe841 Cys216 His351
P0A953	P12785	Lys326 His331 Phe745 Val758 Cys161 His293
P0A953	P19096	Lys326 His331 Phe745 Val758 Cys161 His293
P0A953	Q558W4	Lys392 His397 Phe896 Phe918 Cys194 His342
P0A953	A1CLY8	Lys361 His366 Phe819 Ala836 Cys181 His320
P0A953	P96284	not aligned not aligned not aligned not aligned Cys216 not aligned
P0A953	P12276	Lys326 His331 Phe744 Val757 Cys161 His293
P0A953	P49327	Lys326 His331 Phe745 Val758 Cys161 His293
P0A953	Q02062	not aligned not aligned not aligned not aligned not aligned not aligned
P0A953	Q54TW0	Lys370 His375 Phe819 Phe841 Cys187 His329
P0A953	Q54FI3	Lys373 His378 Phe896 Phe913 Cys198 His338
P0A953	P19097	Lys676 Thr681 Val864 not aligned Ser307 Thr644
P0A953	Q10289	Lys636 Thr641 Ile822 not aligned Thr306 Ser604
P0A953	I1S166	Lys365 His370 Phe838 Ile855 Cys179 His318
P0A953	Q03131	Lys2318 His2323 Phe2759 Phe2774 Cys2148 His2283
P0A953	Q03132	Lys1829 His1834 Phe2264 Phe2279 Cys1661 His1796
P0A953	Q65Z23	Lys724 His729 Phe1169 Trp1185 Cys555 His690
P0A953	Q8NXE1	Lys336 His341 Leu398 Phe400 Cys165 His304
P0A953	Q7TXL8	Lys379 His384 Phe822 Phe836 Cys210 His345
P0A953	Q9ZGI2	Lys377 His382 not aligned not aligned Cys207 His342
P0A953	Q9ZGI3	Lys379 His384 not aligned not aligned Cys209 His344
P0A953	Q9ZGI4	Lys1882 His1887 Phe2318 Phe2334 Cys1712 His1847
P0A953	P0A954	Lys328 His333 Phe390 Phe392 Cys163 His298
P0A953	S4W172	Lys353 His358 Phe806 Ala823 Cys177 His316
P0A953	A0A0E4AZP0	Lys353 His358 Phe806 Ala823 Cys177 His316
P0A953	A0JJU1	Lys369 His374 Phe862 Ala879 Cys189 His326
P0A953	A0A089FSA4	Lys351 His356 Phe825 Ala842 Cys178 His317
P0A953	D7PI15	Lys736 His741 Phe1171 Trp1190 Cys563 His698
P0A953	Q3S2T9	Lys403 His408 Phe872 Gly889 Cys222 His361
P0A953	Q7TXL7	Lys378 His383 Phe810 Phe824 Cys207 His342
P0A953	P9WQE4	Lys372 His377 Phe807 Phe825 Cys205 His340
P0A953	B4XYB8	Lys351 His356 Phe790 Phe805 Cys181 His316
P0A953	Q9Y8A5	Lys362 His367 Phe828 Gly845 Cys181 His320
P0A953	P9WQE2	Lys378 His383 Phe810 Phe824 Cys207 His342
P0A953	A0A084API3	Lys350 His355 Phe1073 Phe1110 Cys180 His315
P0A953	Q8J0F7	Lys362 His367 Phe828 Ala845 Cys181 His320
P0A953	A0A0Y0M151	Lys352 His357 Phe814 Leu835 Cys182 His317
P0A953	D7PHZ2	Lys742 His747 Phe1191 Trp1210 Cys569 His704
P0A953	C5H882	Lys719 His724 Phe1153 Trp1169 Cys549 His684
P0A953	Q8J0F5	Lys367 His372 Phe837 Ile858 Cys202 His337
P0A953	Q3S2U6	Lys348 His353 Phe812 Ile833 Cys183 His318
P0A953	F1DBA9	Lys693 His698 His1078 Phe1080 Cys524 His659
P0A953	A0A0N7D745	Lys712 His717 Phe1150 Trp1166 Cys543 His678
P0A953	A0A1R3RGK0	Lys350 His355 Phe829 Phe867 Cys182 His317
P0A953	P9WQE6	Lys443 His448 Phe878 Phe896 Cys273 His408
P0A953	Q7TVK8	Lys362 His367 Phe801 Phe816 Cys196 His331
P0A953	D2E9X0	Lys394 His399 Phe852 Leu871 Cys221 His358
P0A953	B3FWT3	Lys352 His357 Phe807 Leu829 Cys182 His317
P0A953	A1KQG0	Lys362 His367 Phe801 Phe816 Cys196 His331
P0A953	P22367	Lys374 His379 Leu812 Phe827 Cys204 His339
P0A953	A0A0R8YWJ7	Lys716 His721 Phe2145 Phe2177 Cys547 His682
P0A953	A5U9F4	Lys362 His367 Phe801 Phe816 Cys196 His331
P0A953	L7XAV2	Lys712 His717 Phe1151 Trp1167 Cys543 His678
P0A953	A0A084B9Z6	Lys740 His745 Phe1180 Trp1196 Cys571 His706
P0A953	N4WHA7	Lys355 His360 Phe798 Val815 Cys183 His319
P0A953	B3FWS8	Lys707 His712 Phe1139 Trp1155 Cys538 His673
P0A953	B3FWU0	Lys356 His361 Phe807 Leu829 Cys186 His321
P0A953	P9WQE0	Lys356 His361 Phe797 Leu812 Cys184 His320
P0A953	A0A097ZPE0	Lys711 His716 His1084 Phe1086 Cys542 His677
P0A953	A0A067XNI2	Lys709 His714 Phe1149 Trp1168 Cys534 His670
P0A953	A0A125R003	Lys707 His712 Phe1150 Trp1166 Cys538 His673
P0A953	Q7TXL9	Lys372 His377 Phe807 Phe825 Cys205 His340
P0A953	Q7TXM0	Lys443 His448 Phe878 Phe896 Cys273 His408
P0A953	Q9ZGI5	Lys1451 His1456 Phe3436 Cys3451 Cys1281 His1416
P0A953	N4WHE3	Lys354 His359 Phe828 Leu850 Cys186 His321
P0A953	Q02251	Lys343 His348 Phe783 Phe798 Cys177 His312
P0A953	Q7TXL6	Lys356 His361 Phe797 Leu812 Cys184 His320
P0A953	B3FWT6	Lys721 His726 Phe1164 Trp1180 Cys551 His686
P0A953	A0A1B4XBH3	Lys348 His353 Phe823 Phe873 Cys178 His313
P0A953	P16538	Lys345 His350 not aligned Phe409 Cys173 His313
P0A953	Q7A6F8	Lys336 His341 Leu398 Phe400 Cys165 His304
P0A953	A0A161CEU9	Lys724 His729 Phe1169 Trp1185 Cys555 His690
P0A953	C5H885	Lys358 His363 Phe822 Leu843 Cys184 His319
P0A953	P04683	Lys326 His331 Phe388 Met390 Cys162 His294
P0A953	P0AAI7	Lys336 His341 Phe399 Phe401 Cys164 His304
P0A953	P04684	Lys326 His331 Phe387 Met389 Cys162 His294
P0A953	Q05357	not aligned not aligned not aligned not aligned not aligned not aligned
P0A953	P36189	Lys326 His331 not aligned not aligned Cys161 His293
P0A953	Q02579	not aligned not aligned not aligned not aligned not aligned not aligned
P0A953	Q5TKS0	Lys329 His334 Leu391 Phe393 Cys158 His297
P0A953	P16539	not aligned not aligned not aligned not aligned Gln165 not aligned
P0A953	P55338	Lys337 His342 Phe399 Phe401 Cys164 His304
P0A953	H8ESN0	Lys340 His345 not aligned not aligned Cys171 His311
P0A953	P43678	Lys345 His350 not aligned Phe409 Cys173 His313
P0A953	Q02578	Lys341 His346 not aligned Phe405 Cys169 His309
P0A953	P16541	not aligned not aligned not aligned not aligned not aligned not aligned
P0A953	Q99VA6	Lys336 His341 Leu398 Phe400 Cys165 His304
P0A953	L7X8J4	Lys351 His356 Phe817 Leu839 Cys182 His316
P0A953	P43098	Lys679 Thr684 Val864 not aligned Ser309 Thr648
P0A953	A0A0N7D4P6	Lys351 His356 Phe817 Leu843 Cys181 His316
P0A953	P06231	Lys325 His330 Phe387 Met389 Cys161 His293
P0A953	D7UQ44	Lys358 His363 Leu925 Tyr927 Cys187 His323
P0A953	Q05356	Lys341 His346 not aligned Phe405 Cys169 His309
P0A953	P63457	Lys341 His346 not aligned not aligned Cys170 His311
P0A953	Q6GIA3	Lys336 His341 Leu398 Phe400 Cys165 His304
P0A953	P63455	Lys340 His345 not aligned not aligned Cys171 His311
P0A953	P0AAI6	Lys336 His341 Phe399 Phe401 Cys164 His304
P0A953	Q02K94	Lys326 His331 Phe389 Phe391 Cys161 His296
P0A953	P16540	Lys341 His346 not aligned Phe405 Cys169 His309
P0A953	P0AAI8	Lys336 His341 Phe399 Phe401 Cys164 His304
P0A953	P9WQD6	Lys341 His346 not aligned not aligned Cys170 His311
P0A953	Q8KA28	Lys331 His336 not aligned not aligned Cys164 His300
P0A953	P72331	Lys326 His331 Phe388 Met390 Cys162 His294
P0A953	P41175	Lys339 His344 not aligned Phe403 Cys169 His307
P0A953	Q5W262	not aligned not aligned not aligned not aligned Asp197 not aligned
P0A953	Q9Y7D5	Lys348 His353 Phe812 Val833 Cys183 His318
P0A953	Q5HHA1	Lys336 His341 Leu398 Phe400 Cys165 His304
P0A953	P23902	Lys384 His389 not aligned not aligned Cys213 His353
P0A953	Q6GAU2	Lys336 His341 Leu398 Phe400 Cys165 His304
P0A953	P9WQE8	Lys362 His367 Phe801 Phe816 Cys196 His331
P0A953	Q30DW5	Lys717 His722 Met1155 Val1174 Cys544 His679
P0A953	P9WQD8	Lys340 His345 not aligned not aligned Cys171 His311
P0A953	A0A0M4L8I7	Lys352 His357 Phe841 Ile857 Cys175 His314
P0A953	R4WH05	Lys348 His353 Phe808 Val835 Cys174 His313
P0A953	D9N1A1	Lys351 His356 Phe814 Ile831 Cys179 His316
P0A953	Q50LG3	Lys255 His260 Tyr691 Phe715 Cys87 His222
P0A953	Q5KTM9	Lys345 His350 Phe833 Phe857 Cys175 His310
P0A953	B1GVX7	Lys355 His360 Leu874 Phe876 Cys178 His317
P0A953	Q2ABP6	Lys363 His368 Phe862 Phe880 Cys194 His329
P0A953	B6HV32	Lys721 His726 His1110 Phe1112 Cys552 His687
P0A953	A0A075TRC0	Lys374 His379 Leu811 Phe826 Cys204 His339
P0A953	G3KLH6	Lys734 His739 Phe1179 Trp1198 Cys561 His696
P0A953	A0A1Y0BRF1	Lys720 His725 His1109 Phe1111 Cys551 His686
P0A953	P0CU67	Lys746 His751 Phe1185 Trp1204 Cys572 His708
P0A953	E9KMQ2	Lys705 His710 Phe1145 Trp1164 Cys536 His671
P0A953	A0A2Z5TM64	Glu2946 His2951 not aligned not aligned Val1398 Ala2879
P0A953	A0A179H2I8	Lys311 His316 Phe836 Leu853 Trp173 His281
P0A953	K3VA96	Lys353 His358 Phe842 Leu868 Cys181 His317