M-CSA Mechanism and Catalytic Site Atlas

Pyruvate, phosphate dikinase (M-CSA:207)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P22983

Reference Sequence	Homologue	Arg337 His455 Ser764 Cys831 Tyr851 Met103 (main-N) Arg92 Lys22 Gly101 (main-N)
P22983	P22983	Arg337 His455 Ser764 Cys831 Tyr851 Met103 Arg92 Lys22 Gly101
P22983	P08839	not aligned His189 Ser450 Cys502 Glu522 not aligned not aligned not aligned Gly10
P22983	Q57962	Arg326 His824 Ser1081 Cys1133 Ser1153 Leu105 not aligned Lys32 Glu103
P22983	Q75KR1	Arg351 His469 Ser780 Cys847 Tyr867 Met119 Arg108 Lys39 Gly117
P22983	P23533	not aligned His190 Ser451 Cys503 Glu523 not aligned not aligned not aligned Gly13
P22983	Q59754	Arg352 His468 Ser777 Cys844 Tyr864 Met107 Arg96 Lys26 Gly105
P22983	O67899	Arg341 His433 Ser757 Cys809 Ser830 Leu104 not aligned Lys27 Pro102
P22983	Q6AVA8	Arg411 His529 Ser840 Cys907 Tyr927 Met179 Arg168 Lys98 Gly177
P22983	P11155	Arg411 His529 Ser840 Cys907 Phe927 Met179 Arg168 Lys98 Gly177
P22983	Q9KZP1	not aligned His186 Ser434 Cys486 Ser506 not aligned not aligned not aligned Gly13
P22983	Q42368	Arg347 His465 Ser776 Cys843 Tyr863 Met115 Arg104 Lys34 Gly113
P22983	O23404	Arg427 His545 Ser855 Cys922 Tyr942 Met195 Arg184 Lys114 Gly193
P22983	Q9YEC5	Arg347 His438 Ser708 Cys762 Ser783 Leu97 not aligned Lys23 Pro95
P22983	P42850	Arg357 His442 Ser704 Cys756 Ser776 Ile128 not aligned Lys23 Ser126
P22983	O83728	Lys317 His442 Ser769 Cys835 Tyr855 Ala98 not aligned Arg28 Asn96
P22983	Q9ZD55	Arg345 His460 Ser769 Cys836 Tyr856 Met108 Arg97 Lys26 Gly106
P22983	P46893	Arg349 His447 Ser718 Cys772 Ser793 Val101 not aligned Lys28 Pro99
P22983	Q55905	Arg355 His442 Ser722 Cys774 Ser795 Leu113 not aligned Lys36 Gln111
P22983	O29548	Arg311 His398 Ser651 Cys703 Ser723 Ile93 not aligned Lys20 Glu91
P22983	Q5HQ85	not aligned His191 Ser452 Cys504 Glu524 not aligned not aligned not aligned Gly13
P22983	P45597	not aligned His460 Ser716 Cys768 Glu788 not aligned not aligned His61 Gly283
P22983	O27190	Arg342 His424 Arg681 not aligned not aligned Ile123 not aligned Lys50 Glu121
P22983	P43922	not aligned His189 Ser450 Cys502 Glu522 not aligned not aligned not aligned Gly10
P22983	P23530	not aligned His191 Ser454 Cys506 Glu526 not aligned not aligned not aligned Gly13
P22983	P75168	not aligned His190 Ser446 Cys498 Glu518 not aligned not aligned not aligned Gly12
P22983	P47668	not aligned His190 Ser446 Cys498 Glu518 not aligned not aligned not aligned Gly12
P22983	P32670	not aligned His301 Ser562 Cys614 Glu634 not aligned not aligned not aligned Gly126
P22983	Q9CJ82	not aligned His191 Ser454 Cys506 Glu526 not aligned not aligned not aligned Gly13
P22983	Q9K0I2	Arg334 His422 Ser700 Cys752 Ser773 Leu100 not aligned Lys23 Glu98
P22983	O31149	not aligned His190 Ser451 Cys503 Glu523 not aligned not aligned not aligned Gly13
P22983	Q9WXI6	not aligned His189 Ser450 Cys502 Glu522 not aligned not aligned not aligned Gly10
P22983	P23538	Arg336 His421 Ser699 Cys751 Ser772 Leu104 not aligned Lys27 Pro102
P22983	D4GYE2	not aligned His191 Ser446 Cys498 Glu518 not aligned not aligned not aligned Leu14
P22983	P23536	not aligned His201 Ser465 Cys517 Glu537 not aligned not aligned not aligned Gly13
P22983	O51508	not aligned His190 Ser452 Cys504 Ser524 not aligned not aligned not aligned Gly11
P22983	P08838	not aligned His189 Ser450 Cys502 Glu522 not aligned not aligned not aligned Gly12
P22983	Q9K8D3	not aligned His190 Ser451 Cys503 Glu523 not aligned not aligned not aligned Gly13
P22983	P77439	not aligned His298 Ser559 Cys611 Glu631 not aligned not aligned not aligned Gly125
P22983	O83026	Arg323 His409 Ser687 Cys739 Ser760 Leu98 not aligned Lys21 Ala96
P22983	P45595	not aligned His191 Ser454 Cys506 Glu526 not aligned not aligned not aligned Gly13
P22983	Q89B04	not aligned His189 Ser450 Cys502 Glu522 not aligned not aligned not aligned Gly10
P22983	P56070	Arg337 His430 Ser709 Cys761 Ser782 Leu98 not aligned Lys21 Ser96
P22983	P0A249	not aligned His189 Ser450 Cys502 Glu522 not aligned not aligned not aligned Gly10
P22983	P22221	Arg417 His535 Ser846 Cys913 Tyr933 Met185 Arg174 Lys104 Gly183
P22983	P51183	not aligned His191 Ser452 Cys504 Glu524 not aligned not aligned not aligned Gly13
P22983	Q42736	Arg420 His538 Ser849 Cys916 Tyr936 Met188 Arg177 Lys107 Gly186
P22983	Q99V14	not aligned His191 Ser452 Cys504 Glu524 not aligned not aligned not aligned Gly13
P22983	Q39734	Arg419 His537 Ser848 Cys915 Tyr935 Met187 Arg176 Lys106 Gly185
P22983	Q9V2H7	Arg357 His441 Ser704 Cys756 Ser776 Ile128 not aligned Lys23 Ala126
P22983	Q9ZMV4	Arg337 His430 Ser709 Cys761 Ser782 Leu98 not aligned Lys21 Ser96
P22983	Q9WXK9	not aligned His191 Ser454 Cys506 Glu526 not aligned not aligned not aligned Gly13
P22983	P51776	Arg348 His464 Ser772 Cys839 Tyr858 Met110 Arg99 Lys30 Gly108
P22983	Q5HH01	not aligned His191 Ser452 Cys504 Glu524 not aligned not aligned not aligned Gly13
P22983	P37213	Arg339 His454 Ser771 Cys839 Tyr859 Met102 Arg91 Lys21 Gly100
P22983	O57830	Arg360 His444 Ser707 Cys759 Ser779 Ile131 not aligned Lys26 Asn129
P22983	Q931U2	not aligned His191 Ser452 Cys504 Glu524 not aligned not aligned not aligned Gly13
P22983	Q8FFD8	not aligned His298 Ser559 Cys611 Glu631 not aligned not aligned not aligned Gly125
P22983	Q4ULI7	Arg344 His459 Ser768 Cys835 Tyr855 Met107 Arg96 Lys26 Gly105
P22983	Q42910	Arg414 His532 Ser843 Cys910 Tyr930 Met182 Arg171 Lys101 Gly180
P22983	P42014	not aligned His195 Ser456 Cys508 Glu528 not aligned not aligned not aligned Gly18
P22983	Q39735	Arg417 His535 Ser846 Cys913 Tyr933 Met185 Arg174 Lys104 Gly183
P22983	O69251	not aligned His190 Ser451 Cys503 Glu523 not aligned not aligned not aligned Gly13
P22983	P23388	not aligned His457 Ser712 Cys764 Glu784 not aligned not aligned Asn56 Gly282
P22983	P30299	not aligned His191 Ser454 Cys506 Glu526 not aligned not aligned not aligned Gly13
P22983	Q84F83	not aligned His189 Ser450 Cys502 Glu522 not aligned not aligned not aligned Gly12
P22983	Q83QP3	not aligned His298 Ser559 Cys611 Glu631 not aligned not aligned not aligned Gly125
P22983	O83018	not aligned His195 Ser456 Cys508 Glu528 not aligned not aligned not aligned Gly18
P22983	Q68WP2	Arg345 His460 Ser769 Cys836 Tyr856 Met108 Arg97 Lys26 Gly106
P22983	Q8NX83	not aligned His191 Ser452 Cys504 Glu524 not aligned not aligned not aligned Gly13
P22983	Q92HI8	Arg344 His459 Ser768 Cys835 Tyr855 Met107 Arg96 Lys26 Gly105
P22983	Q6GI01	not aligned His191 Ser452 Cys504 Glu524 not aligned not aligned not aligned Gly13
P22983	Q8XBQ8	not aligned His298 Ser559 Cys611 Glu631 not aligned not aligned not aligned Gly125
P22983	Q8KA50	not aligned His189 Ser450 Cys502 Glu522 not aligned not aligned not aligned Gly10
P22983	P0A250	not aligned His189 Ser450 Cys502 Glu522 not aligned not aligned not aligned Gly10
P22983	P45617	not aligned His190 Ser450 Cys502 Ala522 not aligned not aligned not aligned Gly13
P22983	Q6GAD0	not aligned His191 Ser452 Cys504 Glu524 not aligned not aligned not aligned Gly13
P22983	Q92D19	not aligned His190 Ser451 Cys503 Glu523 not aligned not aligned not aligned Gly13
P22983	Q1RH78	Arg344 His459 Ser768 Cys835 Tyr855 Met107 Arg96 Lys26 Gly105
P22983	Q02KR1	Arg331 His418 Ser696 Cys748 Ser769 Leu99 not aligned Lys22 Ala97
P22983	O07126	not aligned His190 Ser451 Cys503 Glu523 not aligned not aligned not aligned Gly12
P22983	Q9ZAD8	not aligned His191 Ser454 Cys506 Glu526 not aligned not aligned not aligned Gly13
P22983	Q8CT19	not aligned His191 Ser452 Cys504 Glu524 not aligned not aligned not aligned Gly13