M-CSA Mechanism and Catalytic Site Atlas

NAD(P)+ transhydrogenase (AB-specific) (M-CSA:116)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of Q2RSB2, Q2RSB4

Reference Sequence	Homologue	Tyr235 Ser138 Asp393 Arg127 Asp135 Gln132
Q2RSB2	P17557	not aligned Thr131 X not aligned Pro128 Asn124
Q2RSB2	Q2RSB2	Tyr235 Ser138 X Arg127 Asp135 Gln132
Q2RSB2	A0QVQ8	not aligned Ala131 X not aligned Pro128 Glu124
Q2RSB2	E1V931	not aligned Ala131 X not aligned Pro128 Glu124
Q2RSB2	P07001	Tyr226 Ser131 X Arg120 Asp128 Gln125
Q2RSB2	P0C186	Tyr235 Ser138 X Arg127 Asp135 Gln132
Q2RSB2	P11024	Tyr288 Ser193 Asp1010 Arg182 Asp190 Gln187
Q2RSB2	P17556	not aligned Thr131 X not aligned Pro128 Asn124
Q2RSB2	P41077	Tyr232 Ser137 X Arg126 Asp134 Gln131
Q2RSB2	P43842	Tyr226 Ser131 X Arg120 Asp128 Gln125
Q2RSB2	P63478	not aligned Ala128 X not aligned Glu125 Asn121
Q2RSB2	P99151	not aligned Ala128 X not aligned Glu125 Asn121
Q2RSB2	P9WQB0	not aligned Ala131 X not aligned Pro128 Asp124
Q2RSB2	P9WQB1	not aligned Ala131 X not aligned Pro128 Asp124
Q2RSB2	Q08352	not aligned Thr129 X not aligned Pro126 Gly122
Q2RSB2	Q13423	Tyr288 Ser193 Asp1010 Arg182 Asp190 Gln187
Q2RSB2	Q2FG29	not aligned Ser130 X not aligned Pro127 Asp123
Q2RSB2	Q2FH00	not aligned Ala128 X not aligned Glu125 Asn121
Q2RSB2	Q2FXL7	not aligned Ser130 X not aligned Pro127 Asp123
Q2RSB2	Q2FYJ2	not aligned Ala128 X not aligned Glu125 Asn121
Q2RSB2	Q2YTD1	not aligned Ser130 X not aligned Pro127 Asp123
Q2RSB2	Q2YY66	not aligned Ala128 X not aligned Glu125 Asn121
Q2RSB2	Q49YD9	not aligned Thr130 X not aligned Pro127 Asp123
Q2RSB2	Q4L750	not aligned Thr130 X not aligned Pro127 Asp123
Q2RSB2	Q5HF65	not aligned Ser130 X not aligned Pro127 Asp123
Q2RSB2	Q5HFY4	not aligned Ala128 X not aligned Glu125 Asn121
Q2RSB2	Q5HNJ6	not aligned Thr130 X not aligned Pro127 Asp123
Q2RSB2	Q8NW54	not aligned Ser130 X not aligned Pro127 Asp123
Q2RSB2	Q61941	Tyr288 Ser193 Asp1010 Arg182 Asp190 Gln187
Q2RSB2	Q6G8L8	not aligned Ser130 X not aligned Pro127 Asp123
Q2RSB2	Q6G9C3	not aligned Ala128 X not aligned Glu125 Asn121
Q2RSB2	Q6GFZ8	not aligned Ser130 X not aligned Pro127 Asp123
Q2RSB2	Q6GGW9	not aligned Ala128 X not aligned Glu125 Asn121
Q2RSB2	Q6LX40	not aligned Thr131 X not aligned Pro128 Asp124
Q2RSB2	Q8CNW8	not aligned Thr130 X not aligned Pro127 Asp123
Q2RSB2	Q8CX61	not aligned Thr130 X not aligned Pro127 Asn123
Q2RSB2	Q8KY18	not aligned Ala131 X not aligned Pro128 Glu124
Q2RSB2	Q8NWQ3	not aligned Ala128 X not aligned Glu125 Asn121
Q2RSB2	Q931P7	not aligned Ser130 X not aligned Pro127 Asp123
Q2RSB2	Q99TF4	not aligned Ser130 X not aligned Pro127 Asp123
Q2RSB2	Q9ALA2	Tyr230 Ser133 X Arg122 Asp130 Gln127
Q2RSB4	Q2RSB4	X X Asp393 X X X
Q2RSB4	P0AB67	X X Asp392 X X X
Q2RSB4	P0AB68	X X Asp392 X X X
Q2RSB4	P0AB69	X X Asp392 X X X
Q2RSB4	P0AB70	X X Asp392 X X X
Q2RSB4	P0C188	X X Asp393 X X X
Q2RSB4	P11024	Tyr288 Ser193 Asp1010 Arg182 Asp190 Gln187
Q2RSB4	P43010	X X Asp404 X X X
Q2RSB4	Q13423	Tyr288 Ser193 Asp1010 Arg182 Asp190 Gln187
Q2RSB4	Q61941	Tyr288 Ser193 Asp1010 Arg182 Asp190 Gln187