PDBsum entry 9ii3

Membrane protein

PDB id: 9ii3

Contents

Protein chains

803 a.a.

347 a.a.

222 a.a.

Ligands

NAG-NAG ×2

GLU ×2

CLR ×2

PDB id:

9ii3

Name:

Membrane protein

Title:

Cryo-em structure of the 2:1 complex of mglu3 and beta-arrestin1

Structure:

Metabotropic glutamate receptor 3. Chain: r, b. Synonym: mglur3. Engineered: yes. Beta-arrestin-1. Chain: a. Synonym: arrestin beta-1,non-visual arrestin-2. Engineered: yes. Scfv30.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: grm3, gprc1c, mglur3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: arrb1, arr1. Mus musculus. Organism_taxid: 10090.

Authors:

T.L.Wen,M.Du,X.Yang,Y.Q.Shen

Key ref:

T.Wen et al. Molecular basis of beta-Arrestin coupling to the metabotropic glutamate receptor mglu3.. Nat chem biol, . PubMed id: 40050438

Date:

19-Jun-24 Release date: 05-Mar-25

Protein chains

Q14832  (GRM3_HUMAN) -  Metabotropic glutamate receptor 3 from Homo sapiens

Seq: 879 a.a.

Struc: 803 a.a.*

Protein chain

P49407  (ARRB1_HUMAN) -  Beta-arrestin-1 from Homo sapiens

Seq: 418 a.a.

Struc: 347 a.a.*

Protein chain

No UniProt id for this chain

Struc: 222 a.a.

* PDB and UniProt seqs differ at 9 residue positions (black crosses)