PDBsum entry 9ebh

Membrane protein

PDB id: 9ebh

Contents

Protein chains

214 a.a.

334 a.a.

230 a.a.

53 a.a.

266 a.a.

Ligands

ADN

PDB id:

9ebh

Name:

Membrane protein

Title:

Human adenosine a3 receptor gi1 complex bound to adenosine

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Mus musculus. Organism_taxid: 10090.

Authors:

L.Zhang,J.I.Mobbs,A.Glukhova,D.M.Thal

Key ref:

L.Zhang et al. (2025). Molecular basis of ligand binding and receptor activa the human a 3 adenosine receptor.. Nat commun, 16, 7674. PubMed id: 40825947 DOI: 10.1038/S41467-025-62872-X

Date:

12-Nov-24 Release date: 20-Aug-25

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 214 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 334 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 53 a.a.

Protein chain

P0DMS8  (AA3R_HUMAN) -  Adenosine receptor A3 from Homo sapiens

Seq: 318 a.a.

Struc: 266 a.a.

* PDB and UniProt seqs differ at 48 residue positions (black crosses)