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UniProt functional annotation for P59768 | ||
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| UniProt code: P59768. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). {ECO:0000250}. |
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| Subunit: | |
G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (PubMed:19713215). The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (By similarity). {ECO:0000250|UniProtKB:P63212, ECO:0000269|PubMed:19713215}. |
| Subcellular location: | |
Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. |
| Tissue specificity: | |
Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain. {ECO:0000269|PubMed:10833460}. |
| Similarity: | |
Belongs to the G protein gamma family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.