PDBsum entry 9dye

Signaling protein

PDB id: 9dye

Contents

Protein chains

215 a.a.

336 a.a.

56 a.a.

285 a.a.

Ligands

YLX

CLR ×2

J40

PDB id:

9dye

Name:

Signaling protein

Title:

Buspirone-bound serotonin 1a (5-ht1a) receptor-goa protein complex

Structure:

Guanine nucleotide-binding protein g(o) subunit alpha. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnao1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Escherichia coli, homo sapiens.

Authors:

A.L.Warren,G.Zilberg,D.Wacker

Key ref:

A.L.Warren et al. (2025). Structural determinants of g protein subtype selectiv the serotonin receptor 5-Ht1a.. Sci adv, 11, u9851. PubMed id: 40749070 DOI: 10.1126/SCIADV.ADU9851

Date:

14-Oct-24 Release date: 13-Aug-25

Protein chain

P09471  (GNAO_HUMAN) -  Guanine nucleotide-binding protein G(o) subunit alpha from Homo sapiens

Seq: 354 a.a.

Struc: 215 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 285 a.a.*

Protein chain

P08908  (5HT1A_HUMAN) -  5-hydroxytryptamine receptor 1A from Homo sapiens

Seq: 422 a.a.

Struc: 285 a.a.*

* PDB and UniProt seqs differ at 115 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????