UniProt functional annotation for P08908



	UniProt functional annotation for P08908

UniProt code: P08908.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8138923, ECO:0000269|PubMed:8393041}.

Subunit: Heterodimer; heterodimerizes with GPER1. Interacts with YIF1B (By similarity). {ECO:0000250|UniProtKB:P19327, ECO:0000269|PubMed:23300088}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}; Multi-pass membrane protein {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}. Cell projection, dendrite {ECO:0000250|UniProtKB:P19327}.

Tissue specificity: Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells. {ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:8393041}.

Disease: Periodic fever, menstrual cycle-dependent (PFMC) [MIM:614674]: A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines. {ECO:0000269|PubMed:21990073}. Note=The disease is caused by variants affecting the gene represented in this entry.

Similarity: Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269\|PubMed:22957663, ECO:0000269\|PubMed:3138543, ECO:0000269\|PubMed:8138923, ECO:0000269\|PubMed:8393041}.


Subunit:		Heterodimer; heterodimerizes with GPER1. Interacts with YIF1B (By similarity). {ECO:0000250\|UniProtKB:P19327, ECO:0000269\|PubMed:23300088}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:22957663, ECO:0000269\|PubMed:3041227, ECO:0000269\|PubMed:3138543, ECO:0000269\|PubMed:8393041}; Multi-pass membrane protein {ECO:0000269\|PubMed:22957663, ECO:0000269\|PubMed:3041227, ECO:0000269\|PubMed:3138543, ECO:0000269\|PubMed:8393041}. Cell projection, dendrite {ECO:0000250\|UniProtKB:P19327}.
Tissue specificity:		Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells. {ECO:0000269\|PubMed:3041227, ECO:0000269\|PubMed:8393041}.
Disease:		Periodic fever, menstrual cycle-dependent (PFMC) [MIM:614674]: A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines. {ECO:0000269\|PubMed:21990073}. Note=The disease is caused by variants affecting the gene represented in this entry.
Similarity:		Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily. {ECO:0000255\|PROSITE-ProRule:PRU00521}.