PDBsum entry 9btw

Membrane protein

PDB id: 9btw

Contents

Protein chains

114 a.a.

37 a.a.

369 a.a.

232 a.a.

339 a.a.

55 a.a.

128 a.a.

Ligands

NAG ×2

PDB id:

9btw

Name:

Membrane protein

Title:

Human amylin3 receptor in complex with gs and cagrilintide

Structure:

Receptor activity-modifying protein 3. Chain: e. Synonym: calcitonin-receptor-like receptor activity-modifying protein 3,crlr activity-modifying protein 3. Engineered: yes. Cagrilintide. Chain: p. Engineered: yes. Calcitonin receptor.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ramp3. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Synthetic: yes. Gene: calcr. Gene: gnas, gnas1, gsp.

Authors:

J.Cao,M.J.Belousoff,R.M.Johnson,P.M.Sexton,D.L.Wootten

Key ref:

J.Cao et al. Human amylin3 receptor in complex with gs and cagrili. To be published, . PubMed id: 40204768

Date:

15-May-24 Release date: 16-Apr-25

Protein chain

O60896  (RAMP3_HUMAN) -  Receptor activity-modifying protein 3 from Homo sapiens

Seq: 148 a.a.

Struc: 114 a.a.

Protein chain

P10997  (IAPP_HUMAN) -  Islet amyloid polypeptide from Homo sapiens

Seq: 89 a.a.

Struc: 37 a.a.*

Protein chain

P30988  (CALCR_HUMAN) -  Calcitonin receptor from Homo sapiens

Seq: 474 a.a.

Struc: 369 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 232 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

* PDB and UniProt seqs differ at 15 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????