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UniProt functional annotation for P10997 | ||
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| UniProt code: P10997. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. |
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| Subunit: | |
Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and fibril formation. {ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:19475663}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:17374526}. |
| Domain: | |
The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation. {ECO:0000269|PubMed:17374526, ECO:0000269|PubMed:19244249, ECO:0000269|PubMed:19475663}. |
| Ptm: | |
Amyloid fibrils are degraded by IDE. |
| Mass spectrometry: | |
Mass=3936; Method=MALDI; Evidence={ECO:0000269|PubMed:17374526}; |
| Miscellaneous: | |
IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. |
| Similarity: | |
Belongs to the calcitonin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.