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UniProt functional annotation for O60896 | ||
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| UniProt code: O60896. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:9620797}. |
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| Subunit: | |
Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1. {ECO:0000250, ECO:0000269|PubMed:23674134}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner. |
| Tissue specificity: | |
Strongly expressed in lung, breast, immune system and fetal tissues. {ECO:0000269|PubMed:9620797}. |
| Similarity: | |
Belongs to the RAMP family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.