PDBsum entry 8yw3

Structural protein

PDB id: 8yw3

Contents

Protein chains

126 a.a.

337 a.a.

226 a.a.

384 a.a.

57 a.a.

30 a.a.

PDB id:

8yw3

Name:

Structural protein

Title:

Cryo-em structure of the retatrutide-bound human glp-1r-gs complex

Structure:

Nanobody-35. Chain: n. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(s) subunit alpha

Source:

Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Expressed in: spodoptera frugiperda.

Authors:

W.Z.Li,Q.T.Zhou,Z.T.Cong,Q.N.Yuan,W.X.Li,F.H.Zhao,H.E.Xu,L.H.Zhao, D.H.Yang,M.W.Wang

Key ref:

W.Z.Li et al. Structural insights into the triple agonism at glp-1r and gcgr manifested by retatrutide. Cell discovery, . PubMed id: 39019866

Date:

29-Mar-24 Release date: 18-Sep-24

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

No UniProt id for this chain

Struc: 337 a.a.

Protein chain

B2Z3V8  (A2CH_PSEU6) -  L-azetidine-2-carboxylate hydrolase from Pseudomonas sp. (strain A2C)

Seq: 240 a.a.

Struc: 226 a.a.*

Protein chain

No UniProt id for this chain

Struc: 384 a.a.

Protein chain

No UniProt id for this chain

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 30 a.a.

* PDB and UniProt seqs differ at 107 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????