PDBsum entry 8sge

Peptide binding protein

PDB id: 8sge

Contents

Protein chains

326 a.a.

Ligands

GOL ×9

ZWS ×2

Waters ×623

PDB id:

8sge

Name:

Peptide binding protein

Title:

Klhdc2 kelch domain with ligand kdrlkz-1

Structure:

Kelch domain-containing protein 2. Chain: a, b. Synonym: hepatocellular carcinoma-associated antigen 33,host cell factor homolog lcp,host cell factor-like protein 1,hclp-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: klhdc2, hca33. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

1.51Å R-factor: 0.180 R-free: 0.207

Authors:

K.M.Digianantonio,M.Bekes,D.R.Langley,K.Zimmerman

Key ref:

C.M.Hickey et al. Structure-Based discovery and characterization of sma molecule ligands and protac degraders that co-Opt the ligase klhdc2 for targeted protein degradation. To be published, . PubMed id: 38177675

Date:

12-Apr-23 Release date: 03-Jan-24

Protein chains

Q9Y2U9  (KLDC2_HUMAN) -  Kelch domain-containing protein 2 from Homo sapiens

Seq: 406 a.a.

Struc: 326 a.a.