PDBsum entry 8zyu

Membrane protein

PDB id: 8zyu

Contents

Protein chains

362 a.a.

221 a.a.

216 a.a.

313 a.a.

Ligands

ARG-ARG-PRO-TYR-ILE-LEU

SRW

PIO

PDB id:

8zyu

Name:

Membrane protein

Title:

Cryo-em structure of neurotensin receptor 1 in complex with beta- arrestin1 and sbi-553 (complex 1)

Structure:

Beta-arrestin-1. Chain: b. Synonym: arrestin beta-1,non-visual arrestin-2. Engineered: yes. Fab30 heavy chain. Chain: d. Engineered: yes. Neurotensin peptide 8-13. Chain: l.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: arrb1, arr1. Expressed in: escherichia coli. Expression_system_taxid: 562. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes.

Authors:

D.Sun,X.Li,Q.Yuan,W.Yin,H.E.Xu,C.Tian

Key ref:

D.Sun et al. (2025). Molecular mechanism of the arrestin-Biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator.. Cell res, 35, 284. PubMed id: 40118988

Date:

18-Jun-24 Release date: 16-Apr-25

Protein chain

P49407  (ARRB1_HUMAN) -  Beta-arrestin-1 from Homo sapiens

Seq: 418 a.a.

Struc: 362 a.a.

Protein chain

No UniProt id for this chain

Struc: 221 a.a.

Protein chain

No UniProt id for this chain

Struc: 216 a.a.

Protein chain

P30989  (NTR1_HUMAN) -  Neurotensin receptor type 1 from Homo sapiens

Seq: 418 a.a.

Struc: 313 a.a.*

* PDB and UniProt seqs differ at 9 residue positions (black crosses)