UniProt functional annotation for P30989



	UniProt functional annotation for P30989

UniProt code: P30989.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). {ECO:0000269|PubMed:21725197, ECO:0000269|PubMed:23140271, ECO:0000269|PubMed:8381365}.

Subunit: Interacts (palmitoylated form) with GNA11. {ECO:0000269|PubMed:21725197, ECO:0000269|PubMed:23140271}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:8381365}; Multi-pass membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:21725197}. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000269|PubMed:21725197}.

Tissue specificity: Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. {ECO:0000269|PubMed:20048080, ECO:0000269|PubMed:8381365}.

Domain: The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7. {ECO:0000250|UniProtKB:P20789}.

Ptm: N-glycosylated. {ECO:0000269|PubMed:21725197}.

Ptm: Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. {ECO:0000269|PubMed:21725197}.

Similarity: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). {ECO:0000269\|PubMed:21725197, ECO:0000269\|PubMed:23140271, ECO:0000269\|PubMed:8381365}.


Subunit:		Interacts (palmitoylated form) with GNA11. {ECO:0000269\|PubMed:21725197, ECO:0000269\|PubMed:23140271}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:8381365}; Multi-pass membrane protein {ECO:0000305}. Membrane raft {ECO:0000269\|PubMed:21725197}. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000269\|PubMed:21725197}.
Tissue specificity:		Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. {ECO:0000269\|PubMed:20048080, ECO:0000269\|PubMed:8381365}.
Domain:		The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7. {ECO:0000250\|UniProtKB:P20789}.
Ptm:		N-glycosylated. {ECO:0000269\|PubMed:21725197}.
Ptm:		Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. {ECO:0000269\|PubMed:21725197}.
Similarity:		Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily. {ECO:0000255\|PROSITE-ProRule:PRU00521}.