PDBsum entry 8zbe

Membrane protein/immune system

PDB id: 8zbe

Contents

Protein chains

263 a.a.

213 a.a.

58 a.a.

233 a.a.

341 a.a.

Ligands

CYS-PHE-DTR-LYS-THR-CYS

PDB id:

8zbe

Name:

Membrane protein/immune system

Title:

Cryo-em structure of the octreotide-bound sstr5-gi complex

Structure:

Beta-2 adrenergic receptor,somatostatin receptor type 5, lgbit (fusion protein). Chain: a. Synonym: beta-2 adrenoreceptor,beta-2 adrenoceptor,ss-5-r,ss5-r,ss5r, sst5. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: b. Synonym: adenylate cyclase-inhibiting g alpha protein.

Source:

Homo sapiens, oplophorus gracilirostris. Human. Organism_taxid: 9606, 727944. Gene: adrb2, adrb2r, b2ar, sstr5. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Organism_taxid: 9606. Gene: gnai1.

Authors:

Y.G.Li,X.Y.Meng,X.R.Yang,S.L.Ling,P.Shi,C.L.Tian,F.Yang

Key ref:

Y.G.Li et al. Structural insights into somatostatin receptor 5 boun cyclic peptides.. Acta pharmacol sin, . PubMed id: 38926478

Date:

26-Apr-24 Release date: 10-Jul-24

Protein chain

P07550  (ADRB2_HUMAN) -  Beta-2 adrenergic receptor from Homo sapiens

Seq: 413 a.a.

Struc: 263 a.a.*

Protein chain

P35346  (SSR5_HUMAN) -  Somatostatin receptor type 5 from Homo sapiens

Seq: 364 a.a.

Struc: 263 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 213 a.a.*

Protein chain

A0A9X9ZA26  (A0A9X9ZA26_RAT) -  Guanine nucleotide-binding protein subunit gamma from Rattus norvegicus

Seq: 71 a.a.

Struc: 58 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 341 a.a.

* PDB and UniProt seqs differ at 188 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.- - ?????