PDBsum entry 8yn5

Signaling protein

PDB id: 8yn5

Contents

Protein chains

224 a.a.

342 a.a.

57 a.a.

230 a.a.

288 a.a.

Ligands

HSM

CLR ×5

PDB id:

8yn5

Name:

Signaling protein

Title:

Cryo-em structure of histamine h3 receptor in complex with histamine and gi

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Synthetic construct.

Authors:

X.Zhang,G.Liu,X.Li,W.Gong

Key ref:

X.Zhang et al. (2024). Structural basis of ligand recognition and activation histamine receptor family. Nat commun, 15, 8296. PubMed id: 39333117

Date:

10-Mar-24 Release date: 09-Oct-24

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 224 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 342 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

Protein chain

Q9Y5N1  (HRH3_HUMAN) -  Histamine H3 receptor from Homo sapiens

Seq: 445 a.a.

Struc: 288 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????