PDBsum entry 8y72

Membrane protein

PDB id: 8y72

Contents

Protein chains

225 a.a.

336 a.a.

56 a.a.

231 a.a.

287 a.a.

Ligands

TYR-DAL-GLY-MEA-ETA

CLR ×2

VV9

PDB id:

8y72

Name:

Membrane protein

Title:

Positive allosteric modulator(bms986122)-bound mu-opioid receptor-gi complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Norway rat. Organism_taxid: 10116.

Authors:

P.Luo,Y.Xu,Y.Wang,Y.Zhuang,H.E.Xu

Key ref:

P.Luo et al. Structure based design of a positive allosteric modul mu-Opioid receptor for synergistic analgesia. To be published, .

Date:

03-Feb-24 Release date: 06-Aug-25

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 225 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

Protein chain

P35372  (OPRM_HUMAN) -  Mu-type opioid receptor from Homo sapiens

Seq: 400 a.a.

Struc: 287 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)