PDBsum entry 8x16

Membrane protein/immune system

PDB id: 8x16

Contents

Protein chains

281 a.a.

217 a.a.

339 a.a.

56 a.a.

233 a.a.

Ligands

Q8L

PDB id:

8x16

Name:

Membrane protein/immune system

Title:

Cryo-em structure of adenosine receptor a3ar bound to cf101

Structure:

Adenosine receptor a3. Chain: r. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: adora3. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Bos taurus. Cattle. Organism_taxid: 9913.

Authors:

H.Cai,Y.Xu,H.E.Xu

Key ref:

H.Cai et al. (2024). Cryo-Em structures of adenosine receptor a3ar bound t selective agonists. Nat commun, 15, 3252. PubMed id: 38627384

Date:

06-Nov-23 Release date: 24-Apr-24

Protein chain

P0DMS8  (AA3R_HUMAN) -  Adenosine receptor A3 from Homo sapiens

Seq: 318 a.a.

Struc: 281 a.a.

Protein chain

P63097  (GNAI1_BOVIN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Bos taurus

Seq: 354 a.a.

Struc: 217 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????