PDBsum entry 8jd6

Membrane protein

PDB id: 8jd6

Contents

Protein chains

761 a.a.

232 a.a.

19 a.a.

301 a.a.

223 a.a.

Ligands

BK0

SEP ×2

PDB id:

8jd6

Name:

Membrane protein

Title:

Cryo-em structure of gi1-bound metabotropic glutamate receptor mglu4

Structure:

Metabotropic glutamate receptor 4. Chain: s, r. Synonym: mglur4. Engineered: yes. Scfv. Chain: d. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: grm4, gprc1d, mglur4. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Escherichia coli. Organism_taxid: 562. Gene: gng2.

Authors:

X.Wang,M.Wang,T.Xu,Y.Feng,S.Han,S.Lin,Q.Zhao,B.Wu

Key ref:

X.Wang et al. Structural insights into dimerization and activation mglu2-Mglu3 and mglu2-Mglu4 heterodimers.. Cell res, . PubMed id: 37286794

Date:

12-May-23 Release date: 21-Jun-23

Protein chains

Q14833  (GRM4_HUMAN) -  Metabotropic glutamate receptor 4 from Homo sapiens

Seq: 912 a.a.

Struc: 761 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 19 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 301 a.a.

Protein chain

P08754  (GNAI3_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-3 from Homo sapiens

Seq: 354 a.a.

Struc: 223 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)