PDBsum entry 8jcv

Membrane protein

PDB id: 8jcv

Contents

Protein chains

763 a.a.

751 a.a.

Ligands

NAG ×2

Z99 ×2

PDB id:

8jcv

Name:

Membrane protein

Title:

Cryo-em structure of mglu2-mglu3 heterodimer in presence of ly341495 (dimerization mode ii)

Structure:

Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a. Chain: 2. Synonym: mglur2,ppiase fkbp1a,12 kda fk506-binding protein,12 kda fkbp,fkbp-12,calstabin-1,fk506-binding protein 1a,fkbp-1a, immunophilin fkbp12,rotamase. Engineered: yes. Other_details: author stated 'all the data are processed in cryosparc with default prameters, as all the other deposition. There should be

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2, fkbp1a, fkbp1, fkbp12. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Gene: grm3, gprc1c, mglur3, mtor. Expression_system_taxid: 1092587

Authors:

X.Wang,M.Wang,T.Xu,Y.Feng,S.Han,Q.Zhao,B.Wu

Key ref:

X.Wang et al. Structural insights into dimerization and activation mglu2-Mglu3 and mglu2-Mglu4 heterodimers.. Cell res, . PubMed id: 37286794

Date:

12-May-23 Release date: 21-Jun-23

Protein chain

P62942  (FKB1A_HUMAN) -  Peptidyl-prolyl cis-trans isomerase FKBP1A from Homo sapiens

Seq: 108 a.a.

Struc: 763 a.a.*

Protein chain

Q14416  (GRM2_HUMAN) -  Metabotropic glutamate receptor 2 from Homo sapiens

Seq: 872 a.a.

Struc: 763 a.a.*

Protein chain

A0A8V8TRG9  (A0A8V8TRG9_HUMAN) -  Serine/threonine-protein kinase mTOR from Homo sapiens

Seq: 2478 a.a.

Struc: 751 a.a.*

Protein chain

Q14832  (GRM3_HUMAN) -  Metabotropic glutamate receptor 3 from Homo sapiens

Seq: 879 a.a.

Struc: 751 a.a.

* PDB and UniProt seqs differ at 793 residue positions (black crosses)

Enzyme reactions

• Enzyme class 1: Chain 2: E.C.5.2.1.8 - peptidylprolyl isomerase.
• Reaction: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
• Enzyme class 2: Chain 3: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site