PDBsum entry 8ia2

Signaling protein/immune system

PDB id: 8ia2

Contents

Protein chains

294 a.a.

74 a.a.

209 a.a.

338 a.a.

56 a.a.

232 a.a.

PDB id:

8ia2

Name:

Signaling protein/immune system

Title:

Structure of c5a bound human c5ar1 in complex with go (composite map)

Structure:

C5a anaphylatoxin chemotactic receptor 1. Chain: a. Synonym: c5a anaphylatoxin chemotactic receptor,c5a-r,c5ar. Engineered: yes. C5a anaphylatoxin. Chain: d. Engineered: yes. Guanine nucleotide-binding protein g(o) subunit alpha. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: c5ar1, c5ar, c5r1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: c5. Expressed in: escherichia coli. Expression_system_taxid: 562.

Authors:

M.K.Yadav,R.Yadav,J.Maharana,R.Banerjee,A.K.Shukla,C.Gati

Key ref:

M.K.Yadav et al. Molecular basis of anaphylatoxin binding, Activation, Signaling bias at complement receptors. Cell(cambridge,Mass ), . PubMed id: 37852260

Date:

07-Feb-23 Release date: 18-Oct-23

Protein chain

P21730  (C5AR1_HUMAN) -  C5a anaphylatoxin chemotactic receptor 1 from Homo sapiens

Seq: 350 a.a.

Struc: 294 a.a.

Protein chain

P01031  (CO5_HUMAN) -  Complement C5 from Homo sapiens

Seq: 1676 a.a.

Struc: 74 a.a.

Protein chain

P09471  (GNAO_HUMAN) -  Guanine nucleotide-binding protein G(o) subunit alpha from Homo sapiens

Seq: 354 a.a.

Struc: 209 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 52 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.- - ?????