PDBsum entry 8hnk

Signaling protein

PDB id: 8hnk

Contents

Protein chains

218 a.a.

336 a.a.

54 a.a.

297 a.a.

73 a.a.

232 a.a.

Ligands

CLR ×2

PDB id:

8hnk

Name:

Signaling protein

Title:

Cxcr3-dngi complex activated by cxcl11

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Escherichia coli, homo sapiens, oplophorus

Authors:

H.Z.Jiao,H.L.Hu

Key ref:

H.Jiao et al. Structural insights into the activation and inhibitio cxc chemokine receptor 3. Nat struct mol biol, . PubMed id: 38177682

Date:

08-Dec-22 Release date: 29-Nov-23

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 218 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 297 a.a.*

Protein chain

P49682  (CXCR3_HUMAN) -  C-X-C chemokine receptor type 3 from Homo sapiens

Seq: 368 a.a.

Struc: 297 a.a.

Protein chain

Q9GV45  (LUCI_OPLGR) -  Oplophorus-luciferin 2-monooxygenase catalytic subunit from Oplophorus gracilirostris

Seq: 196 a.a.

Struc: 297 a.a.*

Protein chain

O14625  (CXL11_HUMAN) -  C-X-C motif chemokine 11 from Homo sapiens

Seq: 94 a.a.

Struc: 73 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 179 residue positions (black crosses)

Enzyme reactions

• Enzyme class 2: Chain A: E.C.3.6.5.- - ?????
• Enzyme class 3: Chain R: E.C.1.13.12.13 - Oplophorus-luciferin 2-monooxygenase.

Pathway:

• Reaction: coelenterazine + O2 = coelenteramide + hnu + CO2

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site