UniProt functional annotation for O14625



	UniProt functional annotation for O14625

UniProt code: O14625.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

Subcellular location: Secreted.

Tissue specificity: High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

Induction: By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN- gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes.

Mass spectrometry: Mass=8303; Method=MALDI; Evidence={ECO:0000269|PubMed:10233762};

Similarity: Belongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.

Sequence caution: Sequence=AAB17374.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.


Subcellular location:		Secreted.
Tissue specificity:		High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.
Induction:		By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN- gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes.
Mass spectrometry:		Mass=8303; Method=MALDI; Evidence={ECO:0000269\|PubMed:10233762};
Similarity:		Belongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.
Sequence caution:		Sequence=AAB17374.1; Type=Erroneous initiation; Evidence={ECO:0000305};