PDBsum entry 8dph

Membrane protein

PDB id: 8dph

Contents

Protein chains

264 a.a.

221 a.a.

336 a.a.

42 a.a.

230 a.a.

Ligands

T4U

CLR ×2

PDB id:

8dph

Name:

Membrane protein

Title:

Cryo-em structure of the 5ht2c receptor (vgv isoform) bound to lorcaserin

Structure:

5-hydroxytryptamine receptor 2c. Chain: a. Synonym: 5-ht-2c,5-ht2c,5-htr2c,5-hydroxytryptamine receptor 1c,5-ht- 1c,5-ht1c,serotonin receptor 2c. Engineered: yes. G-alpha subunit q (gi2-mini-gq chimeric). Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: htr2c, htr1c. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Gene: gnb1. Gene: gng2. Expression_system_taxid: 274590

Authors:

R.H.Gumpper,J.F.Fay,B.L.Roth

Key ref:

R.H.Gumpper et al. (2022). Molecular insights into the regulation of constitutiv activity by RNA editing of 5ht2c serotonin receptors. Cell rep, 40, . PubMed id: 35977511

Date:

15-Jul-22 Release date: 24-Aug-22

Protein chain

P28335  (5HT2C_HUMAN) -  5-hydroxytryptamine receptor 2C from Homo sapiens

Seq: 458 a.a.

Struc: 264 a.a.*

Protein chain

No UniProt id for this chain

Struc: 221 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 42 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

* PDB and UniProt seqs differ at 3 residue positions (black crosses)