UniProt functional annotation for P28335



	UniProt functional annotation for P28335

UniProt code: P28335.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,- dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}.

Subunit: Interacts with MPDZ. Interacts with ARRB2. {ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:16319069}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}; Multi-pass membrane protein {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}.

Tissue specificity: Detected in brain. {ECO:0000269|PubMed:8812491}.

Domain: The PDZ domain-binding motif is involved in the interaction with MPDZ. {ECO:0000269|PubMed:11150294}.

Ptm: N-glycosylated. {ECO:0000269|PubMed:11150294}.

Rna editing: Modified_positions=156 {ECO:0000269|PubMed:9928237}, 158 {ECO:0000269|PubMed:9928237}, 160 {ECO:0000269|PubMed:9928237}; Note=Partially edited. RNA editing generates receptor isoforms that differ in their ability to interact with the phospholipase C signaling cascade in a transfected cell line, suggesting that this RNA processing event may contribute to the modulation of serotonergic neurotransmission in the central nervous system.;

Polymorphism: Position 23 is polymorphic; the frequencies in unrelated Caucasians are 0.87 for Cys and 0.13 for Ser. {ECO:0000269|PubMed:7557992}.

Similarity: Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,- dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. {ECO:0000269\|PubMed:12970106, ECO:0000269\|PubMed:18703043, ECO:0000269\|PubMed:19057895, ECO:0000269\|PubMed:7895773}.


Subunit:		Interacts with MPDZ. Interacts with ARRB2. {ECO:0000269\|PubMed:11150294, ECO:0000269\|PubMed:16319069}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:12970106, ECO:0000269\|PubMed:18703043, ECO:0000269\|PubMed:19057895, ECO:0000269\|PubMed:7895773}; Multi-pass membrane protein {ECO:0000269\|PubMed:12970106, ECO:0000269\|PubMed:18703043, ECO:0000269\|PubMed:19057895, ECO:0000269\|PubMed:7895773}.
Tissue specificity:		Detected in brain. {ECO:0000269\|PubMed:8812491}.
Domain:		The PDZ domain-binding motif is involved in the interaction with MPDZ. {ECO:0000269\|PubMed:11150294}.
Ptm:		N-glycosylated. {ECO:0000269\|PubMed:11150294}.
Rna editing:		Modified_positions=156 {ECO:0000269\|PubMed:9928237}, 158 {ECO:0000269\|PubMed:9928237}, 160 {ECO:0000269\|PubMed:9928237}; Note=Partially edited. RNA editing generates receptor isoforms that differ in their ability to interact with the phospholipase C signaling cascade in a transfected cell line, suggesting that this RNA processing event may contribute to the modulation of serotonergic neurotransmission in the central nervous system.;
Polymorphism:		Position 23 is polymorphic; the frequencies in unrelated Caucasians are 0.87 for Cys and 0.13 for Ser. {ECO:0000269\|PubMed:7557992}.
Similarity:		Belongs to the G-protein coupled receptor 1 family. {ECO:0000255\|PROSITE-ProRule:PRU00521}.