PDBsum entry 7tyh

Membrane protein

PDB id: 7tyh

Contents

Protein chains

229 a.a.

338 a.a.

54 a.a.

127 a.a.

97 a.a.

33 a.a.

369 a.a.

PDB id:

7tyh

Name:

Membrane protein

Title:

Human amylin2 receptor in complex with gs and human calcitonin peptide

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Lama glama.

Authors:

J.Cao,M.J.Belousoff,R.M.Johnson,D.L.Wootten,P.M.Sexton

Key ref:

J.Cao et al. A structural basis for amylin receptor phenotype. To be published, . PubMed id: 35324283

Date:

13-Feb-22 Release date: 23-Mar-22

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 229 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

Protein chain

No UniProt id for this chain

Struc: 127 a.a.

Protein chain

O60895  (RAMP2_HUMAN) -  Receptor activity-modifying protein 2 from Homo sapiens

Seq: 175 a.a.

Struc: 97 a.a.

Protein chain

P01258  (CALC_HUMAN) -  Calcitonin from Homo sapiens

Seq: 141 a.a.

Struc: 33 a.a.*

Protein chain

P30988  (CALCR_HUMAN) -  Calcitonin receptor from Homo sapiens

Seq: 474 a.a.

Struc: 369 a.a.

* PDB and UniProt seqs differ at 53 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????