PDBsum entry 7lly

Membrane protein

PDB id: 7lly

Contents

Protein chains

196 a.a.

339 a.a.

57 a.a.

128 a.a.

26 a.a.

355 a.a.

PDB id:

7lly

Name:

Membrane protein

Title:

Oxyntomodulin-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs protein

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Lama glama.

Authors:

D.Wootten,P.M.Sexton,M.J.Belousoff,R.Danev,X.Zhang,M.Khoshouei, H.Venugopal

Key ref:

y.l.liang et al. (2022). Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13, 92-92. PubMed id: 35013280

Date:

04-Feb-21 Release date: 12-Jan-22

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 196 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

P01274  (GLUC_PIG) -  Pro-glucagon from Sus scrofa

Seq: 180 a.a.

Struc: 26 a.a.

Protein chain

P43220  (GLP1R_HUMAN) -  Glucagon-like peptide 1 receptor from Homo sapiens

Seq: 463 a.a.

Struc: 355 a.a.*

* PDB and UniProt seqs differ at 39 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????

Nat Commun 13:92-92 (2022)

PubMed id: 35013280

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.

y.l.liang, g.deganutti, x.zhang, m.khoshouei, l.clydesdalm.bellousoff, h.venugopal, t.t.truong, a.glukhova, a.kellk.j.gregory, k.leach, a.christopoulos, r.danev, c.a.reynop.zhao, p.m.sexton, d.wootten.

ABSTRACT

No abstract given.