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UniProt functional annotation for P43220 | ||
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| UniProt code: P43220. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
G-protein coupled receptor for glucagon-like peptide 1 (GLP- 1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). {ECO:0000250|UniProtKB:O35659, ECO:0000269|PubMed:19861722, ECO:0000269|PubMed:26308095, ECO:0000269|PubMed:27196125, ECO:0000269|PubMed:28514449, ECO:0000269|PubMed:7517895, ECO:0000269|PubMed:8216285, ECO:0000269|PubMed:8405712}. |
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| Activity regulation: | |
The allosteric modulators NNC0640, PF-06372222 and MK-0893 inhibit the increase of intracellular cAMP levels in response to GLP-1. {ECO:0000269|PubMed:28514449}. |
| Subunit: | |
May form homodimers and heterodimers with GIPR. {ECO:0000269|PubMed:18287102, ECO:0000269|PubMed:22412906}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:19861722, ECO:0000269|PubMed:26308095, ECO:0000269|PubMed:27196125, ECO:0000269|PubMed:28514449, ECO:0000269|PubMed:7517895, ECO:0000269|PubMed:8216285, ECO:0000269|PubMed:8405712}; Multi-pass membrane protein {ECO:0000269|PubMed:28514449}. |
| Ptm: | |
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER. {ECO:0000269|PubMed:22412906}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 2 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.