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PDBsum entry 6twh
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Viral protein
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PDB id
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6twh
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Contents |
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(+ 0 more)
316 a.a.
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(+ 0 more)
172 a.a.
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References listed in PDB file
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Key reference
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Title
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Hemagglutinin traits determine transmission of avian a/h10n7 influenza virus between mammals.
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Authors
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S.Herfst,
J.Zhang,
M.Richard,
R.Mcbride,
P.Lexmond,
T.M.Bestebroer,
M.I.J.Spronken,
D.De meulder,
J.M.Van den brand,
M.E.Rosu,
S.R.Martin,
S.J.Gamblin,
X.Xiong,
W.Peng,
R.Bodewes,
E.Van der vries,
A.D.M.E.Osterhaus,
J.C.Paulson,
J.J.Skehel,
R.A.M.Fouchier.
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Ref.
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Cell Host Microbe, 2020,
28,
602.
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PubMed id
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Abstract
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In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along
North-European coastal waters, significantly impacting seal populations. Here,
we examine the cross-species transmission and mammalian adaptation of this
influenza A virus, revealing changes in the hemagglutinin surface protein that
increase stability and receptor binding. The seal A/H10N7 virus was aerosol or
respiratory droplet transmissible between ferrets. Compared with avian H10
hemagglutinin, seal H10 hemagglutinin showed stronger binding to the human-type
sialic acid receptor, with preferential binding to α2,6-linked sialic acids on
long extended branches. In X-ray structures, changes in the 220-loop of the
receptor-binding pocket caused similar interactions with human receptor as seen
for pandemic strains. Two substitutions made seal H10 hemagglutinin more stable
than avian H10 hemagglutinin and similar to human hemagglutinin. Consequently,
identification of avian-origin influenza viruses across mammals appears critical
to detect influenza A viruses posing a major threat to humans and other mammals.
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