PDBsum entry 4zoj

Transferase/transferase inhibitor

PDB id: 4zoj

Contents

Protein chains

341 a.a.

Ligands

PRP ×2

61L ×2

PO4

IMD

Metals

_MG ×4

Waters ×288

PDB id:

4zoj

Name:

Transferase/transferase inhibitor

Title:

Methylsulfanyl-containing inhibitor bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)

Structure:

Anthranilate phosphoribosyltransferase. Chain: a, b. Engineered: yes

Source:

Mycobacterium tuberculosis h37ra. Organism_taxid: 419947. Strain: atcc 25177 / h37ra. Gene: trpd, mra_2208. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.96Å R-factor: 0.217 R-free: 0.259

Authors:

G.L.Evans,E.N.Baker,J.S.Lott,Tb Structural Genomics Consortium (Tbsgc)

Key ref:

G.L.Evans et al. Inhibitor bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase ( trpd).. To be published, .

Date:

06-May-15 Release date: 11-May-16

Protein chains

A5U4M0  (TRPD_MYCTA) -  Anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)

Seq: 370 a.a.

Struc: 341 a.a.

Enzyme reactions

• Enzyme class: E.C.2.4.2.18 - anthranilate phosphoribosyltransferase.
• Pathway: Tryptophan Biosynthesis
• Reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha- D-ribose 1-diphosphate + anthranilate

N-(5-phospho-beta-D-ribosyl)anthranilate (Bound ligand (Het Group name = PRP) matches with 40.91% similarity) + diphosphate (Bound ligand (Het Group name = 61L) matches with 53.57% similarity) = 5-phospho-alpha- D-ribose 1-diphosphate + anthranilate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site