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PDBsum entry 4d0d
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Immune system
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PDB id
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4d0d
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References listed in PDB file
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Key reference
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Title
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Expression levels of mhc class i molecules are inversely correlated with promiscuity of peptide binding.
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Authors
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P.Chappell,
E.L. .K.Meziane,
M.Harrison,
..Magiera,
C.Hermann,
L.Mears,
A.G.Wrobel,
C.Durant,
L.L.Nielsen,
S.Buus,
N.Ternette,
W.Mwangi,
C.Butter,
V.Nair,
T.Ahyee,
R.Duggleby,
A.Madrigal,
P.Roversi,
S.M.Lea,
J.Kaufman.
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Ref.
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Elife, 2015,
4,
e05345.
[DOI no: ]
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PubMed id
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Abstract
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Highly polymorphic major histocompatibility complex (MHC) molecules are at the
heart of adaptive immune responses, playing crucial roles in many kinds of
disease and in vaccination. We report that breadth of peptide presentation and
level of cell surface expression of class I molecules are inversely correlated
in both chickens and humans. This relationship correlates with protective
responses against infectious pathogens including Marek's disease virus leading
to lethal tumours in chickens and human immunodeficiency virus infection
progressing to AIDS in humans. We propose that differences in peptide binding
repertoire define two groups of MHC class I molecules strategically evolved as
generalists and specialists for different modes of pathogen resistance. We
suggest that differences in cell surface expression level ensure the development
of optimal peripheral T cell responses. The inverse relationship of peptide
repertoire and expression is evidently a fundamental property of MHC molecules,
with ramifications extending beyond immunology and medicine to evolutionary
biology and conservation.
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