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PDBsum entry 4cyc
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Transcription
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PDB id
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4cyc
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References listed in PDB file
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Key reference
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Title
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A flexible extension of the drosophila ultrabithorax homeodomain defines a novel hox/pbc interaction mode.
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Authors
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N.Foos,
C.Maurel-Zaffran,
M.J.Maté,
R.Vincentelli,
M.Hainaut,
H.Berenger,
J.Pradel,
A.J.Saurin,
M.Ortiz-Lombardía,
Y.Graba.
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Ref.
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Structure, 2015,
23,
270-279.
[DOI no: ]
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PubMed id
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Abstract
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The patterning function of Hox proteins relies on assembling protein complexes
with PBC proteins, which often involves a protein motif found in most Hox
proteins, the so-called Hexapeptide (HX). Hox/PBC complexes likely gained
functional diversity by acquiring additional modes of interaction. Here, we
structurally characterize the first HX alternative interaction mode based on the
paralogue-specific UbdA motif and further functionally validate structure-based
predictions. The UbdA motif folds as a flexible extension of the homeodomain
recognition helix and defines Hox/PBC contacts that occur, compared with those
mediated by the HX motif, on the opposing side of the DNA double helix. This
provides a new molecular facet to Hox/PBC complex assembly and suggests possible
mechanisms for the diversification of Hox protein function.
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