PDBsum entry 3ngr

Transferase

PDB id: 3ngr

Contents

Protein chain

117 a.a.

Ligands

PO4

Waters ×17

PDB id:

3ngr

Name:

Transferase

Title:

Crystal structure of leishmania nucleoside diphosphate kinase b with unordered nucleotide-binding loop.

Structure:

Nucleoside diphosphate kinase. Chain: a. Engineered: yes

Source:

Leishmania major. Organism_taxid: 5664. Gene: l1648.07, lmjf32.2950, ndkb. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.95Å R-factor: 0.257 R-free: 0.351

Authors:

D.M.Trindade,T.A.C.B.Sousa,C.C.C.Tonoli,C.R.Santos,R.K.Arni,R.J.Ward, A.H.C.Oliveira,M.T.Murakami

Key ref:

T.A.Souza et al. (2011). Molecular adaptability of nucleoside diphosphate kinase b from trypanosomatid parasites: stability, oligomerization and structural determinants of nucleotide binding. Mol Biosyst, 7, 2189-2195. PubMed id: 21528129

Date:

13-Jun-10 Release date: 27-Apr-11

Protein chain

Q9U1E1  (Q9U1E1_LEIMA) -  Nucleoside diphosphate kinase from Leishmania major

Seq: 151 a.a.

Struc: 117 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.4.6 - nucleoside-diphosphate kinase.
• Reaction:
  1. a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP
  2. a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Mol Biosyst 7:2189-2195 (2011)

PubMed id: 21528129

Molecular adaptability of nucleoside diphosphate kinase b from trypanosomatid parasites: stability, oligomerization and structural determinants of nucleotide binding.

T.A.Souza, D.M.Trindade, C.C.Tonoli, C.R.Santos, R.J.Ward, R.K.Arni, A.H.Oliveira, M.T.Murakami.

ABSTRACT

No abstract given.