EC - Nucleoside-diphosphate kinase

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IntEnz Enzyme Nomenclature


Accepted name:
nucleoside-diphosphate kinase
Other names:
UDP kinase
nucleoside 5'-diphosphate kinase
nucleoside diphosphate (UDP) kinase
nucleoside diphosphokinase
nucleotide phosphate kinase
uridine diphosphate kinase
Systematic name:
ATP:nucleoside-diphosphate phosphotransferase



Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00409
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004550
CAS Registry Number: 9026-51-1
UniProtKB/Swiss-Prot: (780) [show] [UniProt]


  1. Berg, P. and Joklik, W.K.
    Enzymatic phosphorylation of nucleoside diphosphates.
    J. Biol. Chem. 210: 657-672 (1954).
  2. Gibson, D.M., Ayengar, P. and Sanadi, D.R.
    Transphosphorylations between nucleoside phosphates.
    Biochim. Biophys. Acta 21: 86-91 (1956).
  3. Kirkland, R.J.A. and Turner, J.F.
    Nucleoside diphosphokinase of pea seeds.
    Biochem. J. 72: 716-720 (1959).
  4. Krebs, H.A. and Hems, R.
    Some reactions of adenosine and inosine phosphates in animal tissues.
    Biochim. Biophys. Acta 12: 172-180 (1953).
  5. Nakamura, H. and Sugino, Y.
    Metabolism of deoxyribonucleotides. 3. Purification and some properties of nucleoside diphosphokinase of calf thymus.
    J. Biol. Chem. 241: 4917-4922 (1966). [PMID: 5925862]
  6. Ratliff, R.L., Weaver, R.H., Lardy, H.A. and Kuby, S.A.
    Nucleoside triphosphate-nucleoside diphosphate transphosphorylase (nucleoside diphosphokinase). I. Isolation of the crystalline enzyme from brewers' yeast.
    J. Biol. Chem. 239: 301-309 (1964).

[EC created 1961]