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PDBsum entry 2vl5
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Immune system
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PDB id
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2vl5
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References listed in PDB file
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Key reference
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Title
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The crystal structure of the pathogenic collagen type ii-Specific mouse monoclonal antibody ciic1 FAB: structure to function analysis.
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Authors
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H.Uysal,
B.Sehnert,
K.S.Nandakumar,
U.Böiers,
H.Burkhardt,
R.Holmdahl,
M.M.Thunnissen.
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Ref.
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Mol Immunol, 2008,
45,
2196-2204.
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PubMed id
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Abstract
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Monoclonal anti-collagen type II antibody CIIC1 is an arthritogenic
autoantibody, which induces arthritis in mice. We crystallized and solved the
structure of CIIC1 Fab molecule. Analysis of structure revealed an interaction
between the CDR regions of one Fab to the CH1 domain of another Fab, which
resembles an antibody-antigen interaction. ELISA experiments confirmed the
cross-reactivity of both the full CIIC1 antibody and a single chain Fv fragment
to other anti-collagen antibodies which are of different isotypes and epitope
specificity. The rheumatoid factor like reactivity of CIIC1 antibody together
with its collagen type II specificity may explain the pathogenicity of this
antibody.
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