PDBsum entry 2pfd

Transferase, lyase

PDB id: 2pfd

Contents

Protein chains

540 a.a. *

* Residue conservation analysis

PDB id:

2pfd

Name:

Transferase, lyase

Title:

Anisotropically refined structure of ftcd

Structure:

Formimidoyltransferase-cyclodeaminase. Chain: a, b, c, d. Synonym: formiminotransferase- cyclodeaminase, ftcd, 58 kda microtubule-binding protein. Engineered: yes

Source:

Rattus norvegicus. Norway rat. Organism_taxid: 10116. Strain: rat. Gene: ftcd. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Resolution:

3.42Å R-factor: 0.241 R-free: 0.249

Authors:

B.K.Poon,X.Chen,M.Lu,F.A.Quiocho,Q.Wang,J.Ma

Key ref:

B.K.Poon et al. Anisotropically refined structure of ftcd. To be published, .

Date:

04-Apr-07 Release date: 24-Apr-07

Protein chains

O88618  (FTCD_RAT) -  Formimidoyltransferase-cyclodeaminase from Rattus norvegicus

Seq: 541 a.a.

Struc: 540 a.a.

Enzyme reactions

• Enzyme class 2: E.C.2.1.2.5 - glutamate formimidoyltransferase.
• Pathway: Histidine Catabolism
• Reaction: 5-formimidoyltetrahydrofolate + L-glutamate = N-formimidoyl-L-glutamate + (6S)-5,6,7,8-tetrahydrofolate
• Cofactor: Pyridoxal 5'-phosphate
• Enzyme class 3: E.C.4.3.1.4 - formimidoyltetrahydrofolate cyclodeaminase.

Pathway:

• Reaction: 5-formimidoyltetrahydrofolate + 2 H⁺ = (6R)-5,10- methenyltetrahydrofolate + NH4⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site