EC 4.3.1.4 - Formimidoyltetrahydrofolate cyclodeaminase

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IntEnz Enzyme Nomenclature
EC 4.3.1.4

Names

Accepted name:
formimidoyltetrahydrofolate cyclodeaminase
Other names:
formiminotetrahydrofolate cyclodeaminase
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)
Systematic name:
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)

Reaction

Comments:

In eukaroytes, occurs as a bifunctional enzyme that also has glutamate formimidoyltransferase (EC 2.1.2.5) activity.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030412
CAS Registry Number: 9032-05-7
UniProtKB/Swiss-Prot:

References

  1. Rabinowitz, J.C. and Pricer, W.E.
    Formimino-tetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid.
    J. Am. Chem. Soc. 78: 5702-5704 (1956).

[EC 4.3.1.4 created 1961, modified 2000]